Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications
<i>Phallus indusiatus</i>, or bamboo mushroom, has been reported for its nutraceutical properties, while its cosmeceutical properties remain unclear. In this study, we conducted extractions of whole, fresh <i>P. indusiatus</i> using both aqueous and ethanolic methods. Among t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/10/5/121 |
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| author | Kanyanat Theeraraksakul Kittitat Jaengwang Kiattawee Choowongkomon Lueacha Tabtimmai |
| author_facet | Kanyanat Theeraraksakul Kittitat Jaengwang Kiattawee Choowongkomon Lueacha Tabtimmai |
| author_sort | Kanyanat Theeraraksakul |
| collection | DOAJ |
| description | <i>Phallus indusiatus</i>, or bamboo mushroom, has been reported for its nutraceutical properties, while its cosmeceutical properties remain unclear. In this study, we conducted extractions of whole, fresh <i>P. indusiatus</i> using both aqueous and ethanolic methods. Among the extracts, ultrasonic-assisted extraction method with DI showed the highest antioxidant activity compared to the others. For cosmeceutical assessment, we evaluated the extracts’ inhibitory effects against ECM-degrading enzymes and found that they exhibited a modest inhibitory effect of approximately 50%. Remarkably, ultrasonic-assisted extraction with DI demonstrated promising cosmeceutical properties. Additionally, pressure-assisted extraction with DI showed a potentially protective effect against H<sub>2</sub>O<sub>2</sub>-induced DNA damage. To investigate the anti-melanogenic effect on MNT-1 cells, we treated them with the extracts and observed a significant decrease in cellular tyrosinase activity under α-MSH stimulation. This resulted in a relative reduction in melanin content. Notably, autoclaving extraction exhibited a significantly greater anti-melanogenic effect than the other extracts at the lowest concentration tested. Furthermore, the extracts demonstrated a reduction in NO production under LPS-induced inflammation. Hot water extraction with DI and ethanol exhibited a stronger anti-inflammatory effect compared to diclofenac, without any cytotoxicity. These findings highlight the hidden cosmeceutical properties of <i>P. indusiatus</i> and suggest its potential use as a bioactive ingredient in cosmetic formulations. |
| first_indexed | 2024-03-10T21:19:47Z |
| format | Article |
| id | doaj.art-814283bf1e7047b39d74cf18d38e2027 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-10T21:19:47Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-814283bf1e7047b39d74cf18d38e20272023-11-19T16:08:18ZengMDPI AGCosmetics2079-92842023-08-0110512110.3390/cosmetics10050121Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic ApplicationsKanyanat Theeraraksakul0Kittitat Jaengwang1Kiattawee Choowongkomon2Lueacha Tabtimmai3Interdisciplinary Program of Genetic Engineering and Bioinformatics, Graduate School, Kasetsart University, Bangkok 10900, ThailandDepartment of Biochemistry, Kasetsart University, Bangkok 10900, ThailandDepartment of Biochemistry, Kasetsart University, Bangkok 10900, ThailandDepartment of Biotechnology, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok 10800, Thailand<i>Phallus indusiatus</i>, or bamboo mushroom, has been reported for its nutraceutical properties, while its cosmeceutical properties remain unclear. In this study, we conducted extractions of whole, fresh <i>P. indusiatus</i> using both aqueous and ethanolic methods. Among the extracts, ultrasonic-assisted extraction method with DI showed the highest antioxidant activity compared to the others. For cosmeceutical assessment, we evaluated the extracts’ inhibitory effects against ECM-degrading enzymes and found that they exhibited a modest inhibitory effect of approximately 50%. Remarkably, ultrasonic-assisted extraction with DI demonstrated promising cosmeceutical properties. Additionally, pressure-assisted extraction with DI showed a potentially protective effect against H<sub>2</sub>O<sub>2</sub>-induced DNA damage. To investigate the anti-melanogenic effect on MNT-1 cells, we treated them with the extracts and observed a significant decrease in cellular tyrosinase activity under α-MSH stimulation. This resulted in a relative reduction in melanin content. Notably, autoclaving extraction exhibited a significantly greater anti-melanogenic effect than the other extracts at the lowest concentration tested. Furthermore, the extracts demonstrated a reduction in NO production under LPS-induced inflammation. Hot water extraction with DI and ethanol exhibited a stronger anti-inflammatory effect compared to diclofenac, without any cytotoxicity. These findings highlight the hidden cosmeceutical properties of <i>P. indusiatus</i> and suggest its potential use as a bioactive ingredient in cosmetic formulations.https://www.mdpi.com/2079-9284/10/5/121<i>P. indusiatus</i>pigmentationextractionantioxidantanti-inflammatory |
| spellingShingle | Kanyanat Theeraraksakul Kittitat Jaengwang Kiattawee Choowongkomon Lueacha Tabtimmai Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications Cosmetics <i>P. indusiatus</i> pigmentation extraction antioxidant anti-inflammatory |
| title | Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications |
| title_full | Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications |
| title_fullStr | Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications |
| title_full_unstemmed | Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications |
| title_short | Exploring the Biological Functions and Anti-Melanogenesis of <i>Phallus indusiatus</i> for Mushroom-Based Cosmetic Applications |
| title_sort | exploring the biological functions and anti melanogenesis of i phallus indusiatus i for mushroom based cosmetic applications |
| topic | <i>P. indusiatus</i> pigmentation extraction antioxidant anti-inflammatory |
| url | https://www.mdpi.com/2079-9284/10/5/121 |
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