Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders
Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies and expand the boundaries of neuropharmacology, studies from the field ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3340 |
| _version_ | 1797240691135348736 |
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| author | Corneliu Toader Nicolaie Dobrin Daniel Costea Luca-Andrei Glavan Razvan-Adrian Covache-Busuioc David-Ioan Dumitrascu Bogdan-Gabriel Bratu Horia-Petre Costin Alexandru Vlad Ciurea |
| author_facet | Corneliu Toader Nicolaie Dobrin Daniel Costea Luca-Andrei Glavan Razvan-Adrian Covache-Busuioc David-Ioan Dumitrascu Bogdan-Gabriel Bratu Horia-Petre Costin Alexandru Vlad Ciurea |
| author_sort | Corneliu Toader |
| collection | DOAJ |
| description | Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies and expand the boundaries of neuropharmacology, studies from the field have highlighted the gut microbiota’s role in modulating these disorders. These alterations may influence the brain’s processes through the brain–gut axis, a multifaceted bidirectional system that establishes a connection between the enteric and central nervous systems. Thus, probiotic and prebiotic supplements that are meant to influence overall gut health may play an insightful role in alleviating psychiatric symptoms, such as the cognitive templates of major depressive disorder, anxiety, or schizophrenia. Moreover, the administration of psychotropic drugs has been revealed to induce specific changes in a microbiome’s diversity, suggesting their potential utility in combating bacterial infections. This review emphasizes the intricate correlations between psychiatric disorders and the gut microbiota, mentioning the promising approaches in regard to the modulation of probiotic and prebiotic treatments, as well as the antimicrobial effects of psychotropic medication. |
| first_indexed | 2024-04-24T18:11:27Z |
| format | Article |
| id | doaj.art-8142bced96d348aab376bbf90682de9a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:27Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8142bced96d348aab376bbf90682de9a2024-03-27T13:45:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256334010.3390/ijms25063340Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric DisordersCorneliu Toader0Nicolaie Dobrin1Daniel Costea2Luca-Andrei Glavan3Razvan-Adrian Covache-Busuioc4David-Ioan Dumitrascu5Bogdan-Gabriel Bratu6Horia-Petre Costin7Alexandru Vlad Ciurea8Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaNeurosurgical Clinic, “Prof. Dr. N. Oblu” Emergency Clinical Hospital, 700309 Iași, RomaniaDepartment of Neurosurgery, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaPsychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies and expand the boundaries of neuropharmacology, studies from the field have highlighted the gut microbiota’s role in modulating these disorders. These alterations may influence the brain’s processes through the brain–gut axis, a multifaceted bidirectional system that establishes a connection between the enteric and central nervous systems. Thus, probiotic and prebiotic supplements that are meant to influence overall gut health may play an insightful role in alleviating psychiatric symptoms, such as the cognitive templates of major depressive disorder, anxiety, or schizophrenia. Moreover, the administration of psychotropic drugs has been revealed to induce specific changes in a microbiome’s diversity, suggesting their potential utility in combating bacterial infections. This review emphasizes the intricate correlations between psychiatric disorders and the gut microbiota, mentioning the promising approaches in regard to the modulation of probiotic and prebiotic treatments, as well as the antimicrobial effects of psychotropic medication.https://www.mdpi.com/1422-0067/25/6/3340gut microbiotaprobioticsantipsychoticsantidepressantsMDDautism |
| spellingShingle | Corneliu Toader Nicolaie Dobrin Daniel Costea Luca-Andrei Glavan Razvan-Adrian Covache-Busuioc David-Ioan Dumitrascu Bogdan-Gabriel Bratu Horia-Petre Costin Alexandru Vlad Ciurea Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders International Journal of Molecular Sciences gut microbiota probiotics antipsychotics antidepressants MDD autism |
| title | Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders |
| title_full | Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders |
| title_fullStr | Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders |
| title_full_unstemmed | Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders |
| title_short | Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders |
| title_sort | mind mood and microbiota gut brain axis in psychiatric disorders |
| topic | gut microbiota probiotics antipsychotics antidepressants MDD autism |
| url | https://www.mdpi.com/1422-0067/25/6/3340 |
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