Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair
Because of the complex nerve anatomy and limited regeneration ability of natural tissue, the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering is a promising method to regener...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2023-01-01
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| Series: | International Journal of Extreme Manufacturing |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2631-7990/acde21 |
| _version_ | 1797792449595179008 |
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| author | Juqing Song Baiheng Lv Wencong Chen Peng Ding Yong He |
| author_facet | Juqing Song Baiheng Lv Wencong Chen Peng Ding Yong He |
| author_sort | Juqing Song |
| collection | DOAJ |
| description | Because of the complex nerve anatomy and limited regeneration ability of natural tissue, the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering is a promising method to regenerate peripheral nerve and spinal cord, and can provide structures and functions similar to natural tissues through scaffold materials and seed cells. Recently, the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions. In this review, we first outlined the anatomy of peripheral nerve and spinal cord, as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical. After that, the design considerations of peripheral nerve and spinal cord tissue engineering were discussed, and various 3D printing technologies applicable to neural tissue engineering were elaborated, including inkjet, extrusion-based, stereolithography, projection-based, and emerging printing technologies. Finally, we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair, as well as the challenges and prospects in this research field. |
| first_indexed | 2024-03-13T02:34:21Z |
| format | Article |
| id | doaj.art-814357e42edb4844a575d98f3c828347 |
| institution | Directory Open Access Journal |
| issn | 2631-7990 |
| language | English |
| last_indexed | 2024-03-13T02:34:21Z |
| publishDate | 2023-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | International Journal of Extreme Manufacturing |
| spelling | doaj.art-814357e42edb4844a575d98f3c8283472023-06-29T09:10:41ZengIOP PublishingInternational Journal of Extreme Manufacturing2631-79902023-01-015303200810.1088/2631-7990/acde21Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repairJuqing Song0Baiheng Lv1Wencong Chen2Peng Ding3Yong He4https://orcid.org/0000-0002-9099-0831School of Mechanical Engineering, Dongguan University of Technology , Dongguan 523808, People’s Republic of ChinaSchool of Mechanical Engineering, Dongguan University of Technology , Dongguan 523808, People’s Republic of ChinaSchool of Mechanical Engineering, Dongguan University of Technology , Dongguan 523808, People’s Republic of ChinaChina Nuclear Power Technology Research Institute Co., Ltd , Shenzhen 518000, People’s Republic of ChinaSchool of Mechanical Engineering, Zhejiang University , Hangzhou 310058, People’s Republic of ChinaBecause of the complex nerve anatomy and limited regeneration ability of natural tissue, the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering is a promising method to regenerate peripheral nerve and spinal cord, and can provide structures and functions similar to natural tissues through scaffold materials and seed cells. Recently, the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions. In this review, we first outlined the anatomy of peripheral nerve and spinal cord, as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical. After that, the design considerations of peripheral nerve and spinal cord tissue engineering were discussed, and various 3D printing technologies applicable to neural tissue engineering were elaborated, including inkjet, extrusion-based, stereolithography, projection-based, and emerging printing technologies. Finally, we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair, as well as the challenges and prospects in this research field.https://doi.org/10.1088/2631-7990/acde21peripheral nerve regenerationspinal cord repair3D printing constructbionic structurebionic function |
| spellingShingle | Juqing Song Baiheng Lv Wencong Chen Peng Ding Yong He Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair International Journal of Extreme Manufacturing peripheral nerve regeneration spinal cord repair 3D printing construct bionic structure bionic function |
| title | Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair |
| title_full | Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair |
| title_fullStr | Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair |
| title_full_unstemmed | Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair |
| title_short | Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair |
| title_sort | advances in 3d printing scaffolds for peripheral nerve and spinal cord injury repair |
| topic | peripheral nerve regeneration spinal cord repair 3D printing construct bionic structure bionic function |
| url | https://doi.org/10.1088/2631-7990/acde21 |
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