PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION
The prevalence of polymorphism -1486T/C of the TLR-9 gene was studied in 44 patients with chronic Epstein-Barr virus infection (CEBV). The control group for the study of the polymorphisms prevalence of -1486T/C of the TLR-9 gene was 40 healthy donors. Three main genotypes of -1486T/C of the TLR-9...
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| Format: | Article |
| Language: | English |
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V. N. Karazin Kharkiv National University
2018-07-01
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| Series: | Journal of V. N. Karazin Kharkiv National University: Series Medicine |
| Subjects: | |
| Online Access: | https://periodicals.karazin.ua/medicine/article/view/11017/10585 |
| _version_ | 1818308271803465728 |
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| author | Lyadova T. I. Ognivenko O. V. Volobueva O. V. Gololobova O. V. Malanchuk S. G. |
| author_facet | Lyadova T. I. Ognivenko O. V. Volobueva O. V. Gololobova O. V. Malanchuk S. G. |
| author_sort | Lyadova T. I. |
| collection | DOAJ |
| description | The prevalence of polymorphism -1486T/C of the TLR-9 gene was studied in 44 patients with chronic
Epstein-Barr virus infection (CEBV). The control group for the study of the polymorphisms prevalence of
-1486T/C of the TLR-9 gene was 40 healthy donors. Three main genotypes of -1486T/C of the TLR-9 gene
were identified based on the obtained results – TT, TC, CC. Investigation of the occurrence frequency of
individual genotypes revealed the dominance of the TC genotype, compared with the homozygous TT and CC
genotypes. The study of -1486T/C of the TLR-9 gene polymorphism frequency distribution for different
genotypes demonstrated the specificity of changes in the TC genotype in patients with CEBV and the absence
of such for the TT and CC genotypes. These results confirm the important role of the TLR-mediated signaling
in the pathogenesis of the disease, which is necessary to determine the genetic background associated with the
course of the disease and its possible consequences. These are the aspects that will further enable the
identification of risk groups among such patients and provide timely therapy. |
| first_indexed | 2024-12-13T07:11:38Z |
| format | Article |
| id | doaj.art-8143e7bfddc54bcca8f21fcc2dfeb11b |
| institution | Directory Open Access Journal |
| issn | 2313-6693 2313-2396 |
| language | English |
| last_indexed | 2024-12-13T07:11:38Z |
| publishDate | 2018-07-01 |
| publisher | V. N. Karazin Kharkiv National University |
| record_format | Article |
| series | Journal of V. N. Karazin Kharkiv National University: Series Medicine |
| spelling | doaj.art-8143e7bfddc54bcca8f21fcc2dfeb11b2022-12-21T23:55:39ZengV. N. Karazin Kharkiv National UniversityJournal of V. N. Karazin Kharkiv National University: Series Medicine2313-66932313-23962018-07-01353745PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTIONLyadova T. I.Ognivenko O. V.Volobueva O. V.Gololobova O. V.Malanchuk S. G.The prevalence of polymorphism -1486T/C of the TLR-9 gene was studied in 44 patients with chronic Epstein-Barr virus infection (CEBV). The control group for the study of the polymorphisms prevalence of -1486T/C of the TLR-9 gene was 40 healthy donors. Three main genotypes of -1486T/C of the TLR-9 gene were identified based on the obtained results – TT, TC, CC. Investigation of the occurrence frequency of individual genotypes revealed the dominance of the TC genotype, compared with the homozygous TT and CC genotypes. The study of -1486T/C of the TLR-9 gene polymorphism frequency distribution for different genotypes demonstrated the specificity of changes in the TC genotype in patients with CEBV and the absence of such for the TT and CC genotypes. These results confirm the important role of the TLR-mediated signaling in the pathogenesis of the disease, which is necessary to determine the genetic background associated with the course of the disease and its possible consequences. These are the aspects that will further enable the identification of risk groups among such patients and provide timely therapy.https://periodicals.karazin.ua/medicine/article/view/11017/10585chronic Epstein-Barr virusToll-like receptorspolymorphismprevalence |
| spellingShingle | Lyadova T. I. Ognivenko O. V. Volobueva O. V. Gololobova O. V. Malanchuk S. G. PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION Journal of V. N. Karazin Kharkiv National University: Series Medicine chronic Epstein-Barr virus Toll-like receptors polymorphism prevalence |
| title | PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION |
| title_full | PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION |
| title_fullStr | PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION |
| title_full_unstemmed | PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION |
| title_short | PREVALENCE OF POLYMORPHISM OF THE TLR-9 TYPE GENE IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION |
| title_sort | prevalence of polymorphism of the tlr 9 type gene in patients with chronic epstein barr virus infection |
| topic | chronic Epstein-Barr virus Toll-like receptors polymorphism prevalence |
| url | https://periodicals.karazin.ua/medicine/article/view/11017/10585 |
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