Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C Virus

Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C Virus

Replication of RNA viruses is characterized by exploration of sequence space which facilitates their adaptation to changing environments. It is generally accepted that such exploration takes place mainly in response to positive selection, and that further diversification is boosted by modifications...

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Bibliographic Details
Main Authors: Carlos García-Crespo, Isabel Gallego, María Eugenia Soria, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Rebeca Lobo-Vega, Elena Moreno, Jordi Gómez, Carlos Briones, Josep Gregori, Josep Quer, Esteban Domingo, Celia Perales
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
viral quasispecies
hepatitis C virus
mutational waves
residue conservation
sequence space
antiviral drug resistance
Online Access:https://www.mdpi.com/1999-4915/13/4/616

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