Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer
Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic inflammatory response to irritants, frequently to tobacco smoke. The progression of COPD from early onset to advanced disease...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/13/2889 |
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| author | Klára Szalontai Nikolett Gémes József Furák Tünde Varga Patrícia Neuperger József Á. Balog László G. Puskás Gábor J. Szebeni |
| author_facet | Klára Szalontai Nikolett Gémes József Furák Tünde Varga Patrícia Neuperger József Á. Balog László G. Puskás Gábor J. Szebeni |
| author_sort | Klára Szalontai |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic inflammatory response to irritants, frequently to tobacco smoke. The progression of COPD from early onset to advanced disease leads to the loss of the alveolar wall, pulmonary hypertension, and fibrosis of the respiratory epithelium. Here, we focus on the epidemiology, progression, and biomarkers of COPD with a particular connection to lung cancer. Dissecting the cellular and molecular players in the progression of the disease, we aim to shed light on the role of smoking, which is responsible for the disease, or at least for the more severe symptoms and worse patient outcomes. We summarize the inflammatory conditions, as well as the role of EMT and fibroblasts in establishing a cancer-prone microenvironment, i.e., the soil for ‘COPD-derived’ lung cancer. We highlight that the major health problem of COPD can be alleviated via smoking cessation, early diagnosis, and abandonment of the usage of biomass fuels on a global basis. |
| first_indexed | 2024-03-10T09:57:51Z |
| format | Article |
| id | doaj.art-8144b41aca7147328250851e16ae8cb7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:57:51Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8144b41aca7147328250851e16ae8cb72023-11-22T02:10:03ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011013288910.3390/jcm10132889Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung CancerKlára Szalontai0Nikolett Gémes1József Furák2Tünde Varga3Patrícia Neuperger4József Á. Balog5László G. Puskás6Gábor J. Szebeni7Csongrád County Hospital of Chest Diseases, Alkotmány u. 36., H6772 Deszk, HungaryLaboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62., H6726 Szeged, HungaryDepartment of Surgery, University of Szeged, Semmelweis u. 8., H6725 Szeged, HungaryLaboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62., H6726 Szeged, HungaryLaboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62., H6726 Szeged, HungaryLaboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62., H6726 Szeged, HungaryLaboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62., H6726 Szeged, HungaryLaboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62., H6726 Szeged, HungaryChronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic inflammatory response to irritants, frequently to tobacco smoke. The progression of COPD from early onset to advanced disease leads to the loss of the alveolar wall, pulmonary hypertension, and fibrosis of the respiratory epithelium. Here, we focus on the epidemiology, progression, and biomarkers of COPD with a particular connection to lung cancer. Dissecting the cellular and molecular players in the progression of the disease, we aim to shed light on the role of smoking, which is responsible for the disease, or at least for the more severe symptoms and worse patient outcomes. We summarize the inflammatory conditions, as well as the role of EMT and fibroblasts in establishing a cancer-prone microenvironment, i.e., the soil for ‘COPD-derived’ lung cancer. We highlight that the major health problem of COPD can be alleviated via smoking cessation, early diagnosis, and abandonment of the usage of biomass fuels on a global basis.https://www.mdpi.com/2077-0383/10/13/2889COPDchronic airway inflammationsmokinglung cancer |
| spellingShingle | Klára Szalontai Nikolett Gémes József Furák Tünde Varga Patrícia Neuperger József Á. Balog László G. Puskás Gábor J. Szebeni Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer Journal of Clinical Medicine COPD chronic airway inflammation smoking lung cancer |
| title | Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer |
| title_full | Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer |
| title_fullStr | Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer |
| title_full_unstemmed | Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer |
| title_short | Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer |
| title_sort | chronic obstructive pulmonary disease epidemiology biomarkers and paving the way to lung cancer |
| topic | COPD chronic airway inflammation smoking lung cancer |
| url | https://www.mdpi.com/2077-0383/10/13/2889 |
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