Virus infections after allogeneic stem cell transplantation in children. Review
Viral infections are a major cause of morbidity and mortality in children after allogeneic stem cell transplantation (HCT). The risk for viral infections or reactivation after HCT depends on the degree of immunosuppression and the duration of immunodeficiency. Although many viral infections frequent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | EJC Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772610X23001290 |
| _version_ | 1797345786269270016 |
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| author | Kerstin Katharina Rauwolf Herbert Pichler |
| author_facet | Kerstin Katharina Rauwolf Herbert Pichler |
| author_sort | Kerstin Katharina Rauwolf |
| collection | DOAJ |
| description | Viral infections are a major cause of morbidity and mortality in children after allogeneic stem cell transplantation (HCT). The risk for viral infections or reactivation after HCT depends on the degree of immunosuppression and the duration of immunodeficiency. Although many viral infections frequently present asymptomatic in affected patients, they can result in severe complications during immunosuppression. Viruses additionally interfere with immune reconstitution after HCT and therefore impact on graft-versus-tumor effects or graft-versus-host disease. This review will focus on clinically relevant viral infections after HCT in children and discuss strategies to prevent viral replication as well as recent advances in diagnostics and treatment. |
| first_indexed | 2024-03-08T11:23:47Z |
| format | Article |
| id | doaj.art-8144e8b10d8d48d6a5dd78a78b0bdce3 |
| institution | Directory Open Access Journal |
| issn | 2772-610X |
| language | English |
| last_indexed | 2024-03-08T11:23:47Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EJC Paediatric Oncology |
| spelling | doaj.art-8144e8b10d8d48d6a5dd78a78b0bdce32024-01-26T05:40:26ZengElsevierEJC Paediatric Oncology2772-610X2023-12-012100131Virus infections after allogeneic stem cell transplantation in children. ReviewKerstin Katharina Rauwolf0Herbert Pichler1Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; Department of Pediatric Hematology and Oncology, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany; Correspondence to: Children's Hospital Zurich – Eleonore Foundation, Balgrist Campus, Lengghalde 5, CH-8008 Zürich, Switzerland.Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, AustriaViral infections are a major cause of morbidity and mortality in children after allogeneic stem cell transplantation (HCT). The risk for viral infections or reactivation after HCT depends on the degree of immunosuppression and the duration of immunodeficiency. Although many viral infections frequently present asymptomatic in affected patients, they can result in severe complications during immunosuppression. Viruses additionally interfere with immune reconstitution after HCT and therefore impact on graft-versus-tumor effects or graft-versus-host disease. This review will focus on clinically relevant viral infections after HCT in children and discuss strategies to prevent viral replication as well as recent advances in diagnostics and treatment.http://www.sciencedirect.com/science/article/pii/S2772610X23001290Allogeneic stem cell transplantationVirusInfectionPediatric |
| spellingShingle | Kerstin Katharina Rauwolf Herbert Pichler Virus infections after allogeneic stem cell transplantation in children. Review EJC Paediatric Oncology Allogeneic stem cell transplantation Virus Infection Pediatric |
| title | Virus infections after allogeneic stem cell transplantation in children. Review |
| title_full | Virus infections after allogeneic stem cell transplantation in children. Review |
| title_fullStr | Virus infections after allogeneic stem cell transplantation in children. Review |
| title_full_unstemmed | Virus infections after allogeneic stem cell transplantation in children. Review |
| title_short | Virus infections after allogeneic stem cell transplantation in children. Review |
| title_sort | virus infections after allogeneic stem cell transplantation in children review |
| topic | Allogeneic stem cell transplantation Virus Infection Pediatric |
| url | http://www.sciencedirect.com/science/article/pii/S2772610X23001290 |
| work_keys_str_mv | AT kerstinkatharinarauwolf virusinfectionsafterallogeneicstemcelltransplantationinchildrenreview AT herbertpichler virusinfectionsafterallogeneicstemcelltransplantationinchildrenreview |