Viral and nonviral delivery systems for gene delivery
Gene therapy is the process of introducing foreign genomic materials into host cells to elicit a therapeutic benefit. Although initially the main focus of gene therapy was on special genetic disorders, now diverse diseases with different patterns of inheritance and acquired diseases are targets of g...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=27;epage=27;aulast=Nayerossadat |
| _version_ | 1798045973924020224 |
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| author | Nouri Nayerossadat Talebi Maedeh Palizban Abas Ali |
| author_facet | Nouri Nayerossadat Talebi Maedeh Palizban Abas Ali |
| author_sort | Nouri Nayerossadat |
| collection | DOAJ |
| description | Gene therapy is the process of introducing foreign genomic materials into host cells to elicit a therapeutic benefit. Although initially the main focus of gene therapy was on special genetic disorders, now diverse diseases with different patterns of inheritance and acquired diseases are targets of gene therapy. There are 2 major categories of gene therapy, including germline gene therapy and somatic gene therapy. Although germline gene therapy may have great potential, because it is currently ethically forbidden, it cannot be used; however, to date human gene therapy has been limited to somatic cells. Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects. In this review we explain about the history of gene therapy, all types of gene delivery systems for germline (nuclei, egg cells, embryonic stem cells, pronuclear, microinjection, sperm cells) and somatic cells by viral [retroviral, adenoviral, adeno association, helper-dependent adenoviral systems, hybrid adenoviral systems, herpes simplex, pox virus, lentivirus, Epstein-Barr virus)] and nonviral systems (physical: Naked DNA, DNA bombardant, electroporation, hydrodynamic, ultrasound, magnetofection) and (chemical: Cationic lipids, different cationic polymers, lipid polymers). In addition to the above-mentioned, advantages, disadvantages, and practical use of each system are discussed. |
| first_indexed | 2024-04-11T23:30:02Z |
| format | Article |
| id | doaj.art-8145e7f9cb394878878db70ed80d8406 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-04-11T23:30:02Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-8145e7f9cb394878878db70ed80d84062022-12-22T03:57:09ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752012-01-0111272710.4103/2277-9175.98152Viral and nonviral delivery systems for gene deliveryNouri NayerossadatTalebi MaedehPalizban Abas AliGene therapy is the process of introducing foreign genomic materials into host cells to elicit a therapeutic benefit. Although initially the main focus of gene therapy was on special genetic disorders, now diverse diseases with different patterns of inheritance and acquired diseases are targets of gene therapy. There are 2 major categories of gene therapy, including germline gene therapy and somatic gene therapy. Although germline gene therapy may have great potential, because it is currently ethically forbidden, it cannot be used; however, to date human gene therapy has been limited to somatic cells. Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects. In this review we explain about the history of gene therapy, all types of gene delivery systems for germline (nuclei, egg cells, embryonic stem cells, pronuclear, microinjection, sperm cells) and somatic cells by viral [retroviral, adenoviral, adeno association, helper-dependent adenoviral systems, hybrid adenoviral systems, herpes simplex, pox virus, lentivirus, Epstein-Barr virus)] and nonviral systems (physical: Naked DNA, DNA bombardant, electroporation, hydrodynamic, ultrasound, magnetofection) and (chemical: Cationic lipids, different cationic polymers, lipid polymers). In addition to the above-mentioned, advantages, disadvantages, and practical use of each system are discussed.http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=27;epage=27;aulast=NayerossadatChemical deliverygene therapynon viral delivery systemsphysical deliveryviral delivery systems |
| spellingShingle | Nouri Nayerossadat Talebi Maedeh Palizban Abas Ali Viral and nonviral delivery systems for gene delivery Advanced Biomedical Research Chemical delivery gene therapy non viral delivery systems physical delivery viral delivery systems |
| title | Viral and nonviral delivery systems for gene delivery |
| title_full | Viral and nonviral delivery systems for gene delivery |
| title_fullStr | Viral and nonviral delivery systems for gene delivery |
| title_full_unstemmed | Viral and nonviral delivery systems for gene delivery |
| title_short | Viral and nonviral delivery systems for gene delivery |
| title_sort | viral and nonviral delivery systems for gene delivery |
| topic | Chemical delivery gene therapy non viral delivery systems physical delivery viral delivery systems |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=27;epage=27;aulast=Nayerossadat |
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