The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?
Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppre...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/2/163 |
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| author | Yuselys García-Martínez Margherita Borriello Giovanna Capolongo Diego Ingrosso Alessandra F. Perna |
| author_facet | Yuselys García-Martínez Margherita Borriello Giovanna Capolongo Diego Ingrosso Alessandra F. Perna |
| author_sort | Yuselys García-Martínez |
| collection | DOAJ |
| description | Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppressive metabolism, gastrointestinal toxicity, and diarrhea. The gut microbiota has emerged as a potential therapeutic target for personalizing immunosuppressive therapy and managing post-transplant complications. This review reports current evidence on gut microbial dysbiosis in kidney transplant recipients, alterations in their gut microbiota associated with kidney transplantation outcomes, and the application of gut microbiota intervention therapies in treating post-transplant complications. |
| first_indexed | 2024-03-11T09:08:05Z |
| format | Article |
| id | doaj.art-8148a5bdf12d4f5bbebe9d5f3341075e |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T09:08:05Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-8148a5bdf12d4f5bbebe9d5f3341075e2023-11-16T19:12:28ZengMDPI AGBiology2079-77372023-01-0112216310.3390/biology12020163The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?Yuselys García-Martínez0Margherita Borriello1Giovanna Capolongo2Diego Ingrosso3Alessandra F. Perna4Department of Translational Medical Science, University of Campania “Luigi Vanvitelli”, Via Pansini, Bldg 17, 80131 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio 7, 80138 Naples, ItalyDepartment of Translational Medical Science, University of Campania “Luigi Vanvitelli”, Via Pansini, Bldg 17, 80131 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio 7, 80138 Naples, ItalyDepartment of Translational Medical Science, University of Campania “Luigi Vanvitelli”, Via Pansini, Bldg 17, 80131 Naples, ItalyKidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppressive metabolism, gastrointestinal toxicity, and diarrhea. The gut microbiota has emerged as a potential therapeutic target for personalizing immunosuppressive therapy and managing post-transplant complications. This review reports current evidence on gut microbial dysbiosis in kidney transplant recipients, alterations in their gut microbiota associated with kidney transplantation outcomes, and the application of gut microbiota intervention therapies in treating post-transplant complications.https://www.mdpi.com/2079-7737/12/2/163kidney transplantationgut microbiotaimmunosuppressive therapypost-transplant infectiondiarrheaallograft rejection |
| spellingShingle | Yuselys García-Martínez Margherita Borriello Giovanna Capolongo Diego Ingrosso Alessandra F. Perna The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy? Biology kidney transplantation gut microbiota immunosuppressive therapy post-transplant infection diarrhea allograft rejection |
| title | The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy? |
| title_full | The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy? |
| title_fullStr | The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy? |
| title_full_unstemmed | The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy? |
| title_short | The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy? |
| title_sort | gut microbiota in kidney transplantation a target for personalized therapy |
| topic | kidney transplantation gut microbiota immunosuppressive therapy post-transplant infection diarrhea allograft rejection |
| url | https://www.mdpi.com/2079-7737/12/2/163 |
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