Prediction of Preeclampsia by First Trimester Combined Test and Simple Complete Blood Count Parameters
Introduction: Preeclampsia is a serious disease which may result in maternal and neonatal mortality and morbidity. Improving the outcome for preeclampsia necessitates early prediction of the disease to identify women at high risk. Measuring blood cell subtype ratios, such as the neutrophil to ly...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6833/15397_CE(Ra1)_F(GH)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Preeclampsia is a serious disease which may result
in maternal and neonatal mortality and morbidity. Improving the
outcome for preeclampsia necessitates early prediction of the
disease to identify women at high risk. Measuring blood cell
subtype ratios, such as the neutrophil to lymphocyte (NLR) and
platelet to lymphocyte (PLR) ratios, might provide prognostic
and diagnostic clues to diseases.
Aim: To investigate hematological changes in early pregnancy,
using simple complete blood count (CBC) and blood
concentrations of beta-human chorionic gonadotropin (β-hCG)
and pregnancy-associated plasma protein-A (PAPP-A) to
determine whether these measures are of any value in the
prediction and early diagnosis of preeclampsia.
Materials and Methods: Six hundred fourteen consecutive
pregnant women with preeclampsia (288 with mild disease
and 326 with severe disease) and 320 uncomplicated pregnant
women were included in the study. Blood samples for routine
CBC and first trimester screen, which combines PAPP-A and
free ß-hCG blood concentrations, were analyzed.
Results: The NLR values were significantly higher in the severe
preeclampsia group compared with the control group (p<0.001).
We also confirmed that levels of PAPP-A were lower in patients
who developed preeclampsia.
Conclusion: Because measuring CBC parameters, particularly
NLR, is fast and easily applicable, they may be used to predict
preeclampsia. |
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| ISSN: | 2249-782X 0973-709X |