Anti-migraine agents from an immunological point of view
Abstract The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The ro...
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-020-02681-6 |
| _version_ | 1818645286272106496 |
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| author | Bakri M. Assas |
| author_facet | Bakri M. Assas |
| author_sort | Bakri M. Assas |
| collection | DOAJ |
| description | Abstract The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CGRP in immune determination, have been studied in depth, with particular focus on its functional significance with respect to common immune challenges i.e., bacterial, viral, fungal and parasitic infections. This review discusses many potential areas of concern in regard to blocking CGRP function and its potential influence on immune milieus during infection, and the risk of adverse effects. Finally, this review recommends specific measures to be taken into consideration when administering anti-CGRP/CGRPR agents. |
| first_indexed | 2024-12-17T00:28:20Z |
| format | Article |
| id | doaj.art-8149c92577ac481abc983a31068b7f5a |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-17T00:28:20Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-8149c92577ac481abc983a31068b7f5a2022-12-21T22:10:25ZengBMCJournal of Translational Medicine1479-58762021-01-011911910.1186/s12967-020-02681-6Anti-migraine agents from an immunological point of viewBakri M. Assas0Faculty of Applied Medical Sciences, Department of Medical Laboratory Technology, Immunology Group, King Abdul Aziz UniversityAbstract The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CGRP in immune determination, have been studied in depth, with particular focus on its functional significance with respect to common immune challenges i.e., bacterial, viral, fungal and parasitic infections. This review discusses many potential areas of concern in regard to blocking CGRP function and its potential influence on immune milieus during infection, and the risk of adverse effects. Finally, this review recommends specific measures to be taken into consideration when administering anti-CGRP/CGRPR agents.https://doi.org/10.1186/s12967-020-02681-6NeuroscienceTherapeutic drug monitoringAdverse drug reactionsImmunologyInfectious diseaseInflammation |
| spellingShingle | Bakri M. Assas Anti-migraine agents from an immunological point of view Journal of Translational Medicine Neuroscience Therapeutic drug monitoring Adverse drug reactions Immunology Infectious disease Inflammation |
| title | Anti-migraine agents from an immunological point of view |
| title_full | Anti-migraine agents from an immunological point of view |
| title_fullStr | Anti-migraine agents from an immunological point of view |
| title_full_unstemmed | Anti-migraine agents from an immunological point of view |
| title_short | Anti-migraine agents from an immunological point of view |
| title_sort | anti migraine agents from an immunological point of view |
| topic | Neuroscience Therapeutic drug monitoring Adverse drug reactions Immunology Infectious disease Inflammation |
| url | https://doi.org/10.1186/s12967-020-02681-6 |
| work_keys_str_mv | AT bakrimassas antimigraineagentsfromanimmunologicalpointofview |