Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review
Objective: The main objectives of this review were, firstly, to study the effect of different physiotherapy interventions on BDNF levels, and, secondly, to analyze the influence of physiotherapy on pain levels to subsequently draw conclusions about its possible relationship with BDNF. Background: Ba...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/1/163 |
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| author | Silvia Di-Bonaventura Josué Fernández-Carnero Luis Matesanz-García Alberto Arribas-Romano Andrea Polli Raúl Ferrer-Peña |
| author_facet | Silvia Di-Bonaventura Josué Fernández-Carnero Luis Matesanz-García Alberto Arribas-Romano Andrea Polli Raúl Ferrer-Peña |
| author_sort | Silvia Di-Bonaventura |
| collection | DOAJ |
| description | Objective: The main objectives of this review were, firstly, to study the effect of different physiotherapy interventions on BDNF levels, and, secondly, to analyze the influence of physiotherapy on pain levels to subsequently draw conclusions about its possible relationship with BDNF. Background: Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and/or maintenance of hyperexcitability of central neurons in pain, it was hypothesized that the levels of this neurotrophic factor may be modified by the application of therapeutic interventions, favoring a reduction in pain intensity. Methods: A literature search of multiple electronic databases (Pubmed, PsycINFO, Medline (Ebsco), Scopus, WOS, Embase) was conducted to identify randomized control trials (RCTs) published without language restrictions up to and including March 2022. The search strategy was based on the combination of medical terms (Mesh) and keywords relating to the following concepts: “pain”, “chronic pain”, “brain derived neurotrophic factor”, “BDNF”, “physiotherapy”, and “physical therapy”. A total of seven papers were included. Results: There were two studies that showed statistically significant differences in pain intensity reduction and an increase in the BDNF levels that used therapies such as rTMS and EIMS in patients with chronic myofascial pain. However, the same conclusions cannot be drawn for the other physical therapies applied. Conclusions: rTMS and EIMS interventions achieved greater short-term reductions in pain intensity and increased BDNF over other types of interventions in chronic myofascial pain patients, as demonstrated by a moderate amount of evidence. In contrast, other types of physical therapy (PT) interventions did not appear to be more effective in decreasing pain intensity and increasing BDNF levels than placebo PT or minimal intervention, as a low amount of evidence was found. |
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| language | English |
| last_indexed | 2024-03-09T11:56:40Z |
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| series | Life |
| spelling | doaj.art-814cefbc44644f49a1f9103e523093722023-11-30T23:08:53ZengMDPI AGLife2075-17292023-01-0113116310.3390/life13010163Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic ReviewSilvia Di-Bonaventura0Josué Fernández-Carnero1Luis Matesanz-García2Alberto Arribas-Romano3Andrea Polli4Raúl Ferrer-Peña5Escuela Internacional de Doctorado, Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, 28933 Alcorcón, SpainDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, 28922 Alcorcón, SpainDepartamento de Fisioterapia, Facultad de Ciencias de la Salud, CSEU La Salle, Universidad Autonóma de Madrid, 28023 Madrid, SpainEscuela Internacional de Doctorado, Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, 28933 Alcorcón, SpainPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Vrije Universiteit Brussel, Pleinlaan 22, 1050 Brussels, BelgiumLa Paz Hospital Institute for Health Research, IdiPAZ, 28029 Madrid, SpainObjective: The main objectives of this review were, firstly, to study the effect of different physiotherapy interventions on BDNF levels, and, secondly, to analyze the influence of physiotherapy on pain levels to subsequently draw conclusions about its possible relationship with BDNF. Background: Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and/or maintenance of hyperexcitability of central neurons in pain, it was hypothesized that the levels of this neurotrophic factor may be modified by the application of therapeutic interventions, favoring a reduction in pain intensity. Methods: A literature search of multiple electronic databases (Pubmed, PsycINFO, Medline (Ebsco), Scopus, WOS, Embase) was conducted to identify randomized control trials (RCTs) published without language restrictions up to and including March 2022. The search strategy was based on the combination of medical terms (Mesh) and keywords relating to the following concepts: “pain”, “chronic pain”, “brain derived neurotrophic factor”, “BDNF”, “physiotherapy”, and “physical therapy”. A total of seven papers were included. Results: There were two studies that showed statistically significant differences in pain intensity reduction and an increase in the BDNF levels that used therapies such as rTMS and EIMS in patients with chronic myofascial pain. However, the same conclusions cannot be drawn for the other physical therapies applied. Conclusions: rTMS and EIMS interventions achieved greater short-term reductions in pain intensity and increased BDNF over other types of interventions in chronic myofascial pain patients, as demonstrated by a moderate amount of evidence. In contrast, other types of physical therapy (PT) interventions did not appear to be more effective in decreasing pain intensity and increasing BDNF levels than placebo PT or minimal intervention, as a low amount of evidence was found.https://www.mdpi.com/2075-1729/13/1/163painbrain derived neurotrophic factorphysical therapy modalitiesmusculoskeletal chronic painelectrotherapyexercise |
| spellingShingle | Silvia Di-Bonaventura Josué Fernández-Carnero Luis Matesanz-García Alberto Arribas-Romano Andrea Polli Raúl Ferrer-Peña Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review Life pain brain derived neurotrophic factor physical therapy modalities musculoskeletal chronic pain electrotherapy exercise |
| title | Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review |
| title_full | Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review |
| title_fullStr | Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review |
| title_full_unstemmed | Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review |
| title_short | Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review |
| title_sort | effect of different physical therapy interventions on brain derived neurotrophic factor levels in chronic musculoskeletal pain patients a systematic review |
| topic | pain brain derived neurotrophic factor physical therapy modalities musculoskeletal chronic pain electrotherapy exercise |
| url | https://www.mdpi.com/2075-1729/13/1/163 |
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