Progression in translational research on spinal cord injury based on microenvironment imbalance
Abstract Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years. Significant progress has been...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-04-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-022-00199-9 |
| _version_ | 1811291086434336768 |
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| author | Baoyou Fan Zhijian Wei Shiqing Feng |
| author_facet | Baoyou Fan Zhijian Wei Shiqing Feng |
| author_sort | Baoyou Fan |
| collection | DOAJ |
| description | Abstract Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years. Significant progress has been made in research on the pathological mechanism of spinal cord injury. In particular, with the development of gene regulation, cell sequencing, and cell tracing technologies, in-depth explorations of the SCI microenvironment have become more feasible. However, translational studies related to repair of the injured spinal cord have not yielded significant results. This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strategies for the injured spinal cord based on microenvironment imbalance, including medications, cell transplantation, exosomes, tissue engineering, cell reprogramming, and rehabilitation. The current state of translational research on SCI and future directions are also discussed. The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction. |
| first_indexed | 2024-04-13T04:24:03Z |
| format | Article |
| id | doaj.art-814e48888119479abbad5d43b5daa6c3 |
| institution | Directory Open Access Journal |
| issn | 2095-6231 |
| language | English |
| last_indexed | 2024-04-13T04:24:03Z |
| publishDate | 2022-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj.art-814e48888119479abbad5d43b5daa6c32022-12-22T03:02:38ZengNature Publishing GroupBone Research2095-62312022-04-0110112610.1038/s41413-022-00199-9Progression in translational research on spinal cord injury based on microenvironment imbalanceBaoyou Fan0Zhijian Wei1Shiqing Feng2Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord InjuryAbstract Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years. Significant progress has been made in research on the pathological mechanism of spinal cord injury. In particular, with the development of gene regulation, cell sequencing, and cell tracing technologies, in-depth explorations of the SCI microenvironment have become more feasible. However, translational studies related to repair of the injured spinal cord have not yielded significant results. This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strategies for the injured spinal cord based on microenvironment imbalance, including medications, cell transplantation, exosomes, tissue engineering, cell reprogramming, and rehabilitation. The current state of translational research on SCI and future directions are also discussed. The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction.https://doi.org/10.1038/s41413-022-00199-9 |
| spellingShingle | Baoyou Fan Zhijian Wei Shiqing Feng Progression in translational research on spinal cord injury based on microenvironment imbalance Bone Research |
| title | Progression in translational research on spinal cord injury based on microenvironment imbalance |
| title_full | Progression in translational research on spinal cord injury based on microenvironment imbalance |
| title_fullStr | Progression in translational research on spinal cord injury based on microenvironment imbalance |
| title_full_unstemmed | Progression in translational research on spinal cord injury based on microenvironment imbalance |
| title_short | Progression in translational research on spinal cord injury based on microenvironment imbalance |
| title_sort | progression in translational research on spinal cord injury based on microenvironment imbalance |
| url | https://doi.org/10.1038/s41413-022-00199-9 |
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