Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei
Glycogen synthase kinase 3 (GSK3) is a vital multifunctional molecule that is widely distributed in invertebrates and vertebrates. GSK3 is a highly conserved serine/threonine (Ser/Thr) protein kinase, which plays an important role in insulin, Wnt, and various signaling pathways. In this study, a GSK...
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Frontiers Media S.A.
2021-06-01
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Series: | Frontiers in Marine Science |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmars.2021.681966/full |
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author | Ying Pang Ying Pang Ying Pang Xiaojun Zhang Xiaojun Zhang Xiaojun Zhang Jianbo Yuan Jianbo Yuan Jianbo Yuan Xiaoxi Zhang Xiaoxi Zhang Manwen Su Manwen Su Fuhua Li Fuhua Li Fuhua Li |
author_facet | Ying Pang Ying Pang Ying Pang Xiaojun Zhang Xiaojun Zhang Xiaojun Zhang Jianbo Yuan Jianbo Yuan Jianbo Yuan Xiaoxi Zhang Xiaoxi Zhang Manwen Su Manwen Su Fuhua Li Fuhua Li Fuhua Li |
author_sort | Ying Pang |
collection | DOAJ |
description | Glycogen synthase kinase 3 (GSK3) is a vital multifunctional molecule that is widely distributed in invertebrates and vertebrates. GSK3 is a highly conserved serine/threonine (Ser/Thr) protein kinase, which plays an important role in insulin, Wnt, and various signaling pathways. In this study, a GSK3 gene were identified in the genome of the Pacific white shrimp, Litopenaeus vannamei, and analyzed its gene structure, phylogeny, and expression profiles. The deduced LvGSK3 protein contains a highly conserved Ser/Thr protein kinase catalytic (S_TKc) domain, the LvGSK3 gene exhibited high expression in different early developmental stages, most adult tissues, and premolting stages. RNA interference of LvGSK3 significantly retarded the increment of body weight and affected the expressions of molting-related genes compared with control groups. These results will improve our understanding of the conserved structure and functions of the LvGSK3 gene and show potential applications of shrimp growth. |
first_indexed | 2024-12-17T07:06:56Z |
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issn | 2296-7745 |
language | English |
last_indexed | 2024-12-17T07:06:56Z |
publishDate | 2021-06-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Marine Science |
spelling | doaj.art-81500428f2d04e1f95552bff514cd9a42022-12-21T21:59:09ZengFrontiers Media S.A.Frontiers in Marine Science2296-77452021-06-01810.3389/fmars.2021.681966681966Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannameiYing Pang0Ying Pang1Ying Pang2Xiaojun Zhang3Xiaojun Zhang4Xiaojun Zhang5Jianbo Yuan6Jianbo Yuan7Jianbo Yuan8Xiaoxi Zhang9Xiaoxi Zhang10Manwen Su11Manwen Su12Fuhua Li13Fuhua Li14Fuhua Li15CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCollege of Earth Science, University of Chinese Academy of Sciences, Beijing, ChinaCAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCollege of Earth Science, University of Chinese Academy of Sciences, Beijing, ChinaCAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCollege of Earth Science, University of Chinese Academy of Sciences, Beijing, ChinaCAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, ChinaCollege of Earth Science, University of Chinese Academy of Sciences, Beijing, ChinaCAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCollege of Earth Science, University of Chinese Academy of Sciences, Beijing, ChinaGlycogen synthase kinase 3 (GSK3) is a vital multifunctional molecule that is widely distributed in invertebrates and vertebrates. GSK3 is a highly conserved serine/threonine (Ser/Thr) protein kinase, which plays an important role in insulin, Wnt, and various signaling pathways. In this study, a GSK3 gene were identified in the genome of the Pacific white shrimp, Litopenaeus vannamei, and analyzed its gene structure, phylogeny, and expression profiles. The deduced LvGSK3 protein contains a highly conserved Ser/Thr protein kinase catalytic (S_TKc) domain, the LvGSK3 gene exhibited high expression in different early developmental stages, most adult tissues, and premolting stages. RNA interference of LvGSK3 significantly retarded the increment of body weight and affected the expressions of molting-related genes compared with control groups. These results will improve our understanding of the conserved structure and functions of the LvGSK3 gene and show potential applications of shrimp growth.https://www.frontiersin.org/articles/10.3389/fmars.2021.681966/fullglycogen synthase kinase 3Litopenaeus vannameigrowthmoltingstructure and function |
spellingShingle | Ying Pang Ying Pang Ying Pang Xiaojun Zhang Xiaojun Zhang Xiaojun Zhang Jianbo Yuan Jianbo Yuan Jianbo Yuan Xiaoxi Zhang Xiaoxi Zhang Manwen Su Manwen Su Fuhua Li Fuhua Li Fuhua Li Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei Frontiers in Marine Science glycogen synthase kinase 3 Litopenaeus vannamei growth molting structure and function |
title | Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei |
title_full | Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei |
title_fullStr | Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei |
title_full_unstemmed | Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei |
title_short | Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei |
title_sort | glycogen synthase kinase 3 gene is important in growth and molting of the pacific white shrimp litopenaeus vannamei |
topic | glycogen synthase kinase 3 Litopenaeus vannamei growth molting structure and function |
url | https://www.frontiersin.org/articles/10.3389/fmars.2021.681966/full |
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