Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2
First described in December 2019 in Wuhan (China), COVID-19 disease rapidly spread worldwide, constituting the biggest pandemic in the last 100 years. Even if SARS-CoV-2, the agent responsible for COVID-19, is mainly associated with pulmonary injury, evidence is growing that this virus can affect ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1397 |
| _version_ | 1797264300617760768 |
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| author | Gauthier Duloquin Thibaut Pommier Marjolaine Georges Maurice Giroud Charles Guenancia Yannick Béjot Gabriel Laurent Claudio Rabec |
| author_facet | Gauthier Duloquin Thibaut Pommier Marjolaine Georges Maurice Giroud Charles Guenancia Yannick Béjot Gabriel Laurent Claudio Rabec |
| author_sort | Gauthier Duloquin |
| collection | DOAJ |
| description | First described in December 2019 in Wuhan (China), COVID-19 disease rapidly spread worldwide, constituting the biggest pandemic in the last 100 years. Even if SARS-CoV-2, the agent responsible for COVID-19, is mainly associated with pulmonary injury, evidence is growing that this virus can affect many organs, including the heart and vascular endothelial cells, and cause haemostasis, CNS, and kidney and gastrointestinal tract abnormalities that can impact in the disease course and prognosis. In fact, COVID-19 may affect almost all the organs. Hence, SARS-CoV-2 is essentially a systemic infection that can present a large number of clinical manifestations, and it is variable in distribution and severity, which means it is potentially life-threatening. The goal of this comprehensive review paper in the series is to give an overview of non-pulmonary involvement in COVID-19, with a special focus on underlying pathophysiological mechanisms and clinical presentation. |
| first_indexed | 2024-04-25T00:26:43Z |
| format | Article |
| id | doaj.art-81545152f7b24effb75c03c968c6c6ad |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:43Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-81545152f7b24effb75c03c968c6c6ad2024-03-12T16:48:18ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135139710.3390/jcm13051397Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2Gauthier Duloquin0Thibaut Pommier1Marjolaine Georges2Maurice Giroud3Charles Guenancia4Yannick Béjot5Gabriel Laurent6Claudio Rabec7Department of Neurology, CHU Dijon-Bourgogne, 21000 Dijon, FranceLaboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2) EA 7460, University of Bourgogne, 21000 Dijon, FranceDepartment of Pneumology and Intensive Care Unit, Reference Centre for Rare Lung Diseases, Dijon University Hospital, 14 Boulevard Gaffarel, 21000 Dijon, FranceDepartment of Neurology, CHU Dijon-Bourgogne, 21000 Dijon, FranceLaboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2) EA 7460, University of Bourgogne, 21000 Dijon, FranceDepartment of Neurology, CHU Dijon-Bourgogne, 21000 Dijon, FranceLaboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2) EA 7460, University of Bourgogne, 21000 Dijon, FranceDepartment of Pneumology and Intensive Care Unit, Reference Centre for Rare Lung Diseases, Dijon University Hospital, 14 Boulevard Gaffarel, 21000 Dijon, FranceFirst described in December 2019 in Wuhan (China), COVID-19 disease rapidly spread worldwide, constituting the biggest pandemic in the last 100 years. Even if SARS-CoV-2, the agent responsible for COVID-19, is mainly associated with pulmonary injury, evidence is growing that this virus can affect many organs, including the heart and vascular endothelial cells, and cause haemostasis, CNS, and kidney and gastrointestinal tract abnormalities that can impact in the disease course and prognosis. In fact, COVID-19 may affect almost all the organs. Hence, SARS-CoV-2 is essentially a systemic infection that can present a large number of clinical manifestations, and it is variable in distribution and severity, which means it is potentially life-threatening. The goal of this comprehensive review paper in the series is to give an overview of non-pulmonary involvement in COVID-19, with a special focus on underlying pathophysiological mechanisms and clinical presentation.https://www.mdpi.com/2077-0383/13/5/1397SARS-CoV-2multiorganicCOVID-19 infection |
| spellingShingle | Gauthier Duloquin Thibaut Pommier Marjolaine Georges Maurice Giroud Charles Guenancia Yannick Béjot Gabriel Laurent Claudio Rabec Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2 Journal of Clinical Medicine SARS-CoV-2 multiorganic COVID-19 infection |
| title | Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2 |
| title_full | Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2 |
| title_fullStr | Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2 |
| title_full_unstemmed | Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2 |
| title_short | Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2 |
| title_sort | is covid 19 infection a multiorganic disease focus on extrapulmonary involvement of sars cov 2 |
| topic | SARS-CoV-2 multiorganic COVID-19 infection |
| url | https://www.mdpi.com/2077-0383/13/5/1397 |
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