Immune microenvironment profiling of gastrointestinal stromal tumors (GIST) shows gene expression patterns associated to immune checkpoint inhibitors response

Immune microenvironment profiling of gastrointestinal stromal tumors (GIST) shows gene expression patterns associated to immune checkpoint inhibitors response

Few studies were conducted investigating the immunological profiles in gastrointestinal stromal tumors (GIST). Adaptive and innate immune cells are present in the tumor microenvironment, indicating GIST as inflamed tumors. In addition, murine models suggested a potential interaction between immune c...

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Bibliographic Details
Main Authors: Maria A. Pantaleo, Giuseppe Tarantino, Claudio Agostinelli, Milena Urbini, Margherita Nannini, Maristella Saponara, Chiara Castelli, Silvia Stacchiotti, Elena Fumagalli, Lidia Gatto, Donatella Santini, Antonio De Leo, Teresa Marafioti, Ayse Akarca, Elena Sabattini, Andrea Pession, Andrea Ardizzoni, Valentina Indio, Annalisa Astolfi
Format: Article
Language:English
Published: Taylor & Francis Group 2019-09-01
Series:OncoImmunology
Subjects:
gastrointestinal stromal tumor
gist
tumor-infiltrating lymphocytes
til
ifn-γ signaling pathway
cd4+ t cells
cd8+ t cells
m2 macrophages
pd-l1 expression
immunotherapy
checkpoint inhibitor
imatinib
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1617588

Internet

http://dx.doi.org/10.1080/2162402X.2019.1617588

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