Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting
BackgroundType 2 diabetes mellitus (T2DM) is a chronic, highly prevalent disease with a significant impact on health. Appropriate treatment requires effective and timely escalation to achieve metabolic control. To evaluate the effectiveness and safety of IDegLira on adults with T2DM previously treat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.828607/full |
| _version_ | 1818009302135209984 |
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| author | Alex Ramírez-Rincón Alex Ramírez-Rincón Carlos E. Builes-Montaño Carlos E. Builes-Montaño Jaime A. Hincapié-García Victor M. Blanco José F. Botero-Arango José F. Botero-Arango |
| author_facet | Alex Ramírez-Rincón Alex Ramírez-Rincón Carlos E. Builes-Montaño Carlos E. Builes-Montaño Jaime A. Hincapié-García Victor M. Blanco José F. Botero-Arango José F. Botero-Arango |
| author_sort | Alex Ramírez-Rincón |
| collection | DOAJ |
| description | BackgroundType 2 diabetes mellitus (T2DM) is a chronic, highly prevalent disease with a significant impact on health. Appropriate treatment requires effective and timely escalation to achieve metabolic control. To evaluate the effectiveness and safety of IDegLira on adults with T2DM previously treated with oral antidiabetics and/or insulin in a real-life setting.MethodsAn observational study in a real-world setting was conducted. Patients were selected from the outpatient clinic of two centers dedicated to specialized diabetes care. Main outcomes were HbA1c, body weight, insulin dose changes, hypoglycemia, and other adverse events.Results67 T2DM patients treated with IDegLira were monitored between 3 and 7 months. At the end of foll ow-up, the median change in HbA1c was -1.05% (CI95% -1.45, -0.65), and a decrease in insulin requirement was also observed (mean difference -10 TDD units (CI95% - 17 to -2.5). No treatment discontinuation was reported, hypoglycemia events were reported in 3 patients at the end of follow-up versus 8 patients at baseline.ConclusionsThis real-life study shows the effectiveness in glycemic control of IDegLira use in T2DM patients who do not achieve goals with other therapies, with an adequate safety profile. The findings need to be confirmed with evaluation of therapeutic results in larger cohorts. |
| first_indexed | 2024-04-14T05:41:17Z |
| format | Article |
| id | doaj.art-81591f40d40345a2961e449619e2cb01 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-14T05:41:17Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-81591f40d40345a2961e449619e2cb012022-12-22T02:09:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-04-011310.3389/fendo.2022.828607828607Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World SettingAlex Ramírez-Rincón0Alex Ramírez-Rincón1Carlos E. Builes-Montaño2Carlos E. Builes-Montaño3Jaime A. Hincapié-García4Victor M. Blanco5José F. Botero-Arango6José F. Botero-Arango7School of Medicine, Universidad Pontificia Bolivariana, Medellín, ColombiaEndocrinology Department, Clínica Integral de Diabetes, Medellín, ColombiaSchool of Medicine, Universidad de Antioquia, Medellín, ColombiaEndocrinology Department, Hospital Pablo Tobón Uribe, Medellín, ColombiaClinical Pharmacology, Pharmaceutical Promotion and Prevention Group, Faculty of Pharmaceutical and Food Sciences, Universidad de Antioquia, Medellín, ColombiaSchool Medicine, Pontificia Universidad Bolivariana, Medellín, ColombiaSchool of Medicine, Universidad Pontificia Bolivariana, Medellín, ColombiaEndocrinology Department, Clínica Integral de Diabetes, Medellín, ColombiaBackgroundType 2 diabetes mellitus (T2DM) is a chronic, highly prevalent disease with a significant impact on health. Appropriate treatment requires effective and timely escalation to achieve metabolic control. To evaluate the effectiveness and safety of IDegLira on adults with T2DM previously treated with oral antidiabetics and/or insulin in a real-life setting.MethodsAn observational study in a real-world setting was conducted. Patients were selected from the outpatient clinic of two centers dedicated to specialized diabetes care. Main outcomes were HbA1c, body weight, insulin dose changes, hypoglycemia, and other adverse events.Results67 T2DM patients treated with IDegLira were monitored between 3 and 7 months. At the end of foll ow-up, the median change in HbA1c was -1.05% (CI95% -1.45, -0.65), and a decrease in insulin requirement was also observed (mean difference -10 TDD units (CI95% - 17 to -2.5). No treatment discontinuation was reported, hypoglycemia events were reported in 3 patients at the end of follow-up versus 8 patients at baseline.ConclusionsThis real-life study shows the effectiveness in glycemic control of IDegLira use in T2DM patients who do not achieve goals with other therapies, with an adequate safety profile. The findings need to be confirmed with evaluation of therapeutic results in larger cohorts.https://www.frontiersin.org/articles/10.3389/fendo.2022.828607/fulltype 2 diabetesinsulin degludecliraglutideIDegLirareal-world evidence (RWE) |
| spellingShingle | Alex Ramírez-Rincón Alex Ramírez-Rincón Carlos E. Builes-Montaño Carlos E. Builes-Montaño Jaime A. Hincapié-García Victor M. Blanco José F. Botero-Arango José F. Botero-Arango Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting Frontiers in Endocrinology type 2 diabetes insulin degludec liraglutide IDegLira real-world evidence (RWE) |
| title | Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting |
| title_full | Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting |
| title_fullStr | Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting |
| title_full_unstemmed | Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting |
| title_short | Short-Term Effectiveness and Reduction in Insulin Requirements in Patients With Type 2 Diabetes Treated With IdegLira in a Real-World Setting |
| title_sort | short term effectiveness and reduction in insulin requirements in patients with type 2 diabetes treated with ideglira in a real world setting |
| topic | type 2 diabetes insulin degludec liraglutide IDegLira real-world evidence (RWE) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.828607/full |
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