The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease
(1) Background: Despite numerous noninvasive methods for assessing liver fibrosis, effective ultrasound parameters remain limited. We aimed to identify easily measurable ultrasound parameters capable of predicting liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and metabolic...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/4/393 |
| _version_ | 1797298490286538752 |
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| author | Jaejun Lee Seungmyeon Choi Seong-Hyun Cho Hyun Yang Pil-Soo Sung Si-Hyun Bae |
| author_facet | Jaejun Lee Seungmyeon Choi Seong-Hyun Cho Hyun Yang Pil-Soo Sung Si-Hyun Bae |
| author_sort | Jaejun Lee |
| collection | DOAJ |
| description | (1) Background: Despite numerous noninvasive methods for assessing liver fibrosis, effective ultrasound parameters remain limited. We aimed to identify easily measurable ultrasound parameters capable of predicting liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and metabolic-dysfunction-associated steatotic liver disease (MASLD); (2) Methods: The data of 994 patients diagnosed with NAFLD via ultrasound at the Armed Forces Goyang Hospital were retrospectively collected from June 2022 to July 2023. A liver stiffness measurement (LSM) ≥ 8.2 kPa was classified as significant fibrosis. Liver steatosis with cardiometabolic risk factors was defined as MASLD. Two ultrasound variables, the portal venous pulsatility index (VPI) and main portal vein diameter (MPVD), were measured; (3) Results: Of 994 patients, 68 had significant fibrosis. Significant differences in VPI (0.27 vs. 0.34, <i>p</i> < 0.001) and MPVD (10.16 mm vs. 8.98 mm, <i>p</i> < 0.001) were observed between the fibrotic and non-fibrotic groups. A logistic analysis adjusted for age and body mass index (BMI) revealed that only VPI (OR of 0.955, <i>p</i> = 0.022, VPI on a 0.01 scale) and MPVD (OR of 1.501, <i>p</i> < 0.001) were significantly associated with significant liver fibrosis. In the MASLD cohort (<i>n</i> = 939), VPI and MPVD were associated with significant fibrosis. To achieve better accuracy in predicting liver fibrosis, we established a nomogram that incorporated MPVD and VPI. The established nomogram was validated in the test cohort, yielding an area under the receiver operating characteristic curve of 0.821 for detecting significant liver fibrosis; (4) Conclusions: VPI and MPVD, as possible surrogate markers, are useful in predicting significant fibrosis in patients with NAFLD and MASLD. |
| first_indexed | 2024-03-07T22:35:35Z |
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| id | doaj.art-815a979a797745f3b2cad484ca9b343f |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-07T22:35:35Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-815a979a797745f3b2cad484ca9b343f2024-02-23T15:13:46ZengMDPI AGDiagnostics2075-44182024-02-0114439310.3390/diagnostics14040393The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver DiseaseJaejun Lee0Seungmyeon Choi1Seong-Hyun Cho2Hyun Yang3Pil-Soo Sung4Si-Hyun Bae5The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Radiology, Armed Forces Goyang Hospital, Goyang 10267, Republic of KoreaDepartment of Internal Medicine, Armed Forces Goyang Hospital, Goyang 10267, Republic of KoreaThe Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaThe Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaThe Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea(1) Background: Despite numerous noninvasive methods for assessing liver fibrosis, effective ultrasound parameters remain limited. We aimed to identify easily measurable ultrasound parameters capable of predicting liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and metabolic-dysfunction-associated steatotic liver disease (MASLD); (2) Methods: The data of 994 patients diagnosed with NAFLD via ultrasound at the Armed Forces Goyang Hospital were retrospectively collected from June 2022 to July 2023. A liver stiffness measurement (LSM) ≥ 8.2 kPa was classified as significant fibrosis. Liver steatosis with cardiometabolic risk factors was defined as MASLD. Two ultrasound variables, the portal venous pulsatility index (VPI) and main portal vein diameter (MPVD), were measured; (3) Results: Of 994 patients, 68 had significant fibrosis. Significant differences in VPI (0.27 vs. 0.34, <i>p</i> < 0.001) and MPVD (10.16 mm vs. 8.98 mm, <i>p</i> < 0.001) were observed between the fibrotic and non-fibrotic groups. A logistic analysis adjusted for age and body mass index (BMI) revealed that only VPI (OR of 0.955, <i>p</i> = 0.022, VPI on a 0.01 scale) and MPVD (OR of 1.501, <i>p</i> < 0.001) were significantly associated with significant liver fibrosis. In the MASLD cohort (<i>n</i> = 939), VPI and MPVD were associated with significant fibrosis. To achieve better accuracy in predicting liver fibrosis, we established a nomogram that incorporated MPVD and VPI. The established nomogram was validated in the test cohort, yielding an area under the receiver operating characteristic curve of 0.821 for detecting significant liver fibrosis; (4) Conclusions: VPI and MPVD, as possible surrogate markers, are useful in predicting significant fibrosis in patients with NAFLD and MASLD.https://www.mdpi.com/2075-4418/14/4/393portal venous pulsatility indexliver fibrosisnonalcoholic fatty liver diseasemetabolic-dysfunction-associated steatotic liver diseasebiomarker |
| spellingShingle | Jaejun Lee Seungmyeon Choi Seong-Hyun Cho Hyun Yang Pil-Soo Sung Si-Hyun Bae The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease Diagnostics portal venous pulsatility index liver fibrosis nonalcoholic fatty liver disease metabolic-dysfunction-associated steatotic liver disease biomarker |
| title | The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease |
| title_full | The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease |
| title_fullStr | The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease |
| title_full_unstemmed | The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease |
| title_short | The Portal Venous Pulsatility Index and Main Portal Vein Diameter as Surrogate Markers for Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Metabolic-Dysfunction-Associated Steatotic Liver Disease |
| title_sort | portal venous pulsatility index and main portal vein diameter as surrogate markers for liver fibrosis in nonalcoholic fatty liver disease and metabolic dysfunction associated steatotic liver disease |
| topic | portal venous pulsatility index liver fibrosis nonalcoholic fatty liver disease metabolic-dysfunction-associated steatotic liver disease biomarker |
| url | https://www.mdpi.com/2075-4418/14/4/393 |
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