Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex
Proper proliferation and differentiation of neural progenitors (NPs) in the developing cerebral cortex are critical for normal brain formation and function. Emerging evidence has shown the importance of microRNAs (miRNAs) in regulating cortical development and the etiology of neurological disorders....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2018.00044/full |
| _version_ | 1828254679472013312 |
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| author | Haijun Zhang Haijun Zhang Longbin Zhang Tao Sun Tao Sun |
| author_facet | Haijun Zhang Haijun Zhang Longbin Zhang Tao Sun Tao Sun |
| author_sort | Haijun Zhang |
| collection | DOAJ |
| description | Proper proliferation and differentiation of neural progenitors (NPs) in the developing cerebral cortex are critical for normal brain formation and function. Emerging evidence has shown the importance of microRNAs (miRNAs) in regulating cortical development and the etiology of neurological disorders. Here we show that miR-26 is co-expressed with its host gene Ctdsp in the mouse embryonic cortex. We demonstrate that similar to its host gene Ctdsp2, miR-26 positively regulates proliferation of NPs through controlling the cell-cycle progression, by using miR-26 overexpression and sponge approaches. On the contrary, miR-26 target gene Emx2 limits expansion of cortical NPs, and promotes transcription of miR-26 host gene Ctdsp. Our study suggests that miR-26, its target Emx2 and its host gene Ctdsp cohesively regulate proliferation of NPs during the mouse cortical development. |
| first_indexed | 2024-04-13T02:01:48Z |
| format | Article |
| id | doaj.art-815b23f7b6ff4108affb7273436275ba |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T02:01:48Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-815b23f7b6ff4108affb7273436275ba2022-12-22T03:07:35ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992018-02-011110.3389/fnmol.2018.00044318132Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral CortexHaijun Zhang0Haijun Zhang1Longbin Zhang2Tao Sun3Tao Sun4Department of Cell and Developmental Biology, Weill Cornell Medical College, Cornell University, New York, NY, United StatesDepartment of Genetic Medicine, Weill Cornell Medical College, Cornell University, New York, NY, United StatesCenter for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, ChinaDepartment of Cell and Developmental Biology, Weill Cornell Medical College, Cornell University, New York, NY, United StatesCenter for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, ChinaProper proliferation and differentiation of neural progenitors (NPs) in the developing cerebral cortex are critical for normal brain formation and function. Emerging evidence has shown the importance of microRNAs (miRNAs) in regulating cortical development and the etiology of neurological disorders. Here we show that miR-26 is co-expressed with its host gene Ctdsp in the mouse embryonic cortex. We demonstrate that similar to its host gene Ctdsp2, miR-26 positively regulates proliferation of NPs through controlling the cell-cycle progression, by using miR-26 overexpression and sponge approaches. On the contrary, miR-26 target gene Emx2 limits expansion of cortical NPs, and promotes transcription of miR-26 host gene Ctdsp. Our study suggests that miR-26, its target Emx2 and its host gene Ctdsp cohesively regulate proliferation of NPs during the mouse cortical development.http://journal.frontiersin.org/article/10.3389/fnmol.2018.00044/fullmiR-26CtdspEmx2neural progenitorcell-cycle progression |
| spellingShingle | Haijun Zhang Haijun Zhang Longbin Zhang Tao Sun Tao Sun Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex Frontiers in Molecular Neuroscience miR-26 Ctdsp Emx2 neural progenitor cell-cycle progression |
| title | Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex |
| title_full | Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex |
| title_fullStr | Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex |
| title_full_unstemmed | Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex |
| title_short | Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex |
| title_sort | cohesive regulation of neural progenitor development by microrna mir 26 its host gene ctdsp and target gene emx2 in the mouse embryonic cerebral cortex |
| topic | miR-26 Ctdsp Emx2 neural progenitor cell-cycle progression |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2018.00044/full |
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