The Relationship between the Oral Microbiota and Metabolic Syndrome
The oral microbiota plays a crucial role in both systemic inflammation and metabolic syndrome (MetS), which is characterised by low-grade inflammation. Studies have analysed the gut microbiota using stool specimens from subjects with MetS; however, the etiological role of the oral microbiota in the...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/3 |
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| author | Yvonne Prince Glenda M. Davison Saarah F. G. Davids Rajiv T. Erasmus Andre P. Kengne Lisa M. Graham Shanel Raghubeer Tandi E. Matsha |
| author_facet | Yvonne Prince Glenda M. Davison Saarah F. G. Davids Rajiv T. Erasmus Andre P. Kengne Lisa M. Graham Shanel Raghubeer Tandi E. Matsha |
| author_sort | Yvonne Prince |
| collection | DOAJ |
| description | The oral microbiota plays a crucial role in both systemic inflammation and metabolic syndrome (MetS), which is characterised by low-grade inflammation. Studies have analysed the gut microbiota using stool specimens from subjects with MetS; however, the etiological role of the oral microbiota in the development of MetS is still uncertain. We investigated the oral microbiota of 128 subgingival plaque samples from a South African cohort with and without MetS. After a comprehensive analysis of the oral microbiota, we observed a significant increase in Gram-positive aerobic and anaerobic microbiota in those with MetS. We observed an abundance of Actinomyces, Corynebacterium, and Fusobacterium genera in the MetS group, which differed significantly from previous studies, which found <i>Granulicatella</i> to be enriched in MetS. To further assess the impact of the metabolic parameters (FBG, Waist C, HDL, TGs, and BP) on the oral microbiota, we calculated the odds ratio (ORs) for significant oral microbiota identified between the MetS groups. We found that different species were associated with at least four MetS risk factors. This study has shown that the oral microbiota is disrupted in MetS and may promote inflammation providing a gateway to other systemic diseases, including diabetes and cardiovascular diseases. |
| first_indexed | 2024-03-09T13:31:16Z |
| format | Article |
| id | doaj.art-815c53bf8b494b8ab8c9fd30a2b4b1aa |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:31:16Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-815c53bf8b494b8ab8c9fd30a2b4b1aa2023-11-30T21:18:01ZengMDPI AGBiomedicines2227-90592022-12-01111310.3390/biomedicines11010003The Relationship between the Oral Microbiota and Metabolic SyndromeYvonne Prince0Glenda M. Davison1Saarah F. G. Davids2Rajiv T. Erasmus3Andre P. Kengne4Lisa M. Graham5Shanel Raghubeer6Tandi E. Matsha7SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7530, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7530, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7530, South AfricaDepartment of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South AfricaNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7530, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7530, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7530, South AfricaThe oral microbiota plays a crucial role in both systemic inflammation and metabolic syndrome (MetS), which is characterised by low-grade inflammation. Studies have analysed the gut microbiota using stool specimens from subjects with MetS; however, the etiological role of the oral microbiota in the development of MetS is still uncertain. We investigated the oral microbiota of 128 subgingival plaque samples from a South African cohort with and without MetS. After a comprehensive analysis of the oral microbiota, we observed a significant increase in Gram-positive aerobic and anaerobic microbiota in those with MetS. We observed an abundance of Actinomyces, Corynebacterium, and Fusobacterium genera in the MetS group, which differed significantly from previous studies, which found <i>Granulicatella</i> to be enriched in MetS. To further assess the impact of the metabolic parameters (FBG, Waist C, HDL, TGs, and BP) on the oral microbiota, we calculated the odds ratio (ORs) for significant oral microbiota identified between the MetS groups. We found that different species were associated with at least four MetS risk factors. This study has shown that the oral microbiota is disrupted in MetS and may promote inflammation providing a gateway to other systemic diseases, including diabetes and cardiovascular diseases.https://www.mdpi.com/2227-9059/11/1/3metabolic syndromeoral microbiotasubgingival plaquerDNAoral microbiotametabolic syndrome |
| spellingShingle | Yvonne Prince Glenda M. Davison Saarah F. G. Davids Rajiv T. Erasmus Andre P. Kengne Lisa M. Graham Shanel Raghubeer Tandi E. Matsha The Relationship between the Oral Microbiota and Metabolic Syndrome Biomedicines metabolic syndrome oral microbiota subgingival plaque rDNA oral microbiota metabolic syndrome |
| title | The Relationship between the Oral Microbiota and Metabolic Syndrome |
| title_full | The Relationship between the Oral Microbiota and Metabolic Syndrome |
| title_fullStr | The Relationship between the Oral Microbiota and Metabolic Syndrome |
| title_full_unstemmed | The Relationship between the Oral Microbiota and Metabolic Syndrome |
| title_short | The Relationship between the Oral Microbiota and Metabolic Syndrome |
| title_sort | relationship between the oral microbiota and metabolic syndrome |
| topic | metabolic syndrome oral microbiota subgingival plaque rDNA oral microbiota metabolic syndrome |
| url | https://www.mdpi.com/2227-9059/11/1/3 |
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