The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption
Orthodontic root resorption (ORR) is an unintended side effect of orthodontic treatment, and severe ORR can affect treatment outcome. Receptor activator of nuclear factor kappa-B ligand (RANKL) has been detected in the resorbed cementum and periodontal (PDL) tissues exposed to excessive orthodontic...
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MDPI AG
2021-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/16/7244 |
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| author | Masaru Yamaguchi Hiroyuki Mishima |
| author_facet | Masaru Yamaguchi Hiroyuki Mishima |
| author_sort | Masaru Yamaguchi |
| collection | DOAJ |
| description | Orthodontic root resorption (ORR) is an unintended side effect of orthodontic treatment, and severe ORR can affect treatment outcome. Receptor activator of nuclear factor kappa-B ligand (RANKL) has been detected in the resorbed cementum and periodontal (PDL) tissues exposed to excessive orthodontic forces. Recent studies have demonstrated that PDL cells and cementoblasts express RANKL that may play a role in ORR during orthodontic tooth movement. It is known that the hardness of cementum in human maxillary premolars differs among individuals. Furthermore, this difference has been reported to be attributed to differences in the calcium (Ca)/phosphorus (P) ratio. A correlation was observed between the Vickers hardness and Ca/P ratio of the cementum in the apical region. These findings suggest that cementum hardness and the Ca/P ratio may be indirectly involved in ORR caused by orthodontic forces. In this review, it aims to identify the role of RANKL and involvement of cementum in ORR. |
| first_indexed | 2024-03-10T09:02:29Z |
| format | Article |
| id | doaj.art-815e21ec560a47b0abb474038cb31145 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:02:29Z |
| publishDate | 2021-08-01 |
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| record_format | Article |
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| spelling | doaj.art-815e21ec560a47b0abb474038cb311452023-11-22T06:38:43ZengMDPI AGApplied Sciences2076-34172021-08-011116724410.3390/app11167244The Role of RANKL and Involvement of Cementum in Orthodontic Root ResorptionMasaru Yamaguchi0Hiroyuki Mishima1Ginza Orthodontic Clinic, Ginza Granvia 6F, 3-3-14 Ginza, Chuo-ku, Tokyo 104-0061, JapanDepartment of Dental Engineering, Tsurumi University School of Dental Medicine, Yokohama 230-8501, JapanOrthodontic root resorption (ORR) is an unintended side effect of orthodontic treatment, and severe ORR can affect treatment outcome. Receptor activator of nuclear factor kappa-B ligand (RANKL) has been detected in the resorbed cementum and periodontal (PDL) tissues exposed to excessive orthodontic forces. Recent studies have demonstrated that PDL cells and cementoblasts express RANKL that may play a role in ORR during orthodontic tooth movement. It is known that the hardness of cementum in human maxillary premolars differs among individuals. Furthermore, this difference has been reported to be attributed to differences in the calcium (Ca)/phosphorus (P) ratio. A correlation was observed between the Vickers hardness and Ca/P ratio of the cementum in the apical region. These findings suggest that cementum hardness and the Ca/P ratio may be indirectly involved in ORR caused by orthodontic forces. In this review, it aims to identify the role of RANKL and involvement of cementum in ORR.https://www.mdpi.com/2076-3417/11/16/7244orthodontic root resorptionRANKLcementumorthodontic tooth movement |
| spellingShingle | Masaru Yamaguchi Hiroyuki Mishima The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption Applied Sciences orthodontic root resorption RANKL cementum orthodontic tooth movement |
| title | The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption |
| title_full | The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption |
| title_fullStr | The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption |
| title_full_unstemmed | The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption |
| title_short | The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption |
| title_sort | role of rankl and involvement of cementum in orthodontic root resorption |
| topic | orthodontic root resorption RANKL cementum orthodontic tooth movement |
| url | https://www.mdpi.com/2076-3417/11/16/7244 |
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