Serum Albumin for Magnetic Nanoparticles Coating
Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. Ho...
| Κύριος συγγραφέας: | |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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MDPI AG
2022-01-01
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| Σειρά: | Magnetochemistry |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.mdpi.com/2312-7481/8/2/13 |
| _version_ | 1827654162045730816 |
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| author | Alexey S. Chubarov |
| author_facet | Alexey S. Chubarov |
| author_sort | Alexey S. Chubarov |
| collection | DOAJ |
| description | Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. However, colloidal stability, biocompatibility, and potential toxicity of MNPs in physiological environments are crucial for their in vivo application. In this context, many research articles focused on the possible procedures for MNPs coating to improve their physic-chemical and biological properties. This review highlights one viable fabrication strategy of biocompatible iron oxide nanoparticles using human serum albumin (HSA). HSA is mainly a transport protein with many functions in various fundamental processes. As it is one of the most abundant plasma proteins, not a single drug in the blood passes without its strength test. It influences the stability, pharmacokinetics, and biodistribution of different drug-delivery systems by binding or forming its protein corona on the surface. The development of albumin-based drug carriers is gaining increasing importance in the targeted delivery of cancer therapy. Considering this, HSA is a highly potential candidate for nanoparticles coating and theranostics area and can provide biocompatibility, prolonged blood circulation, and possibly resolve the drug-resistance cancer problem. |
| first_indexed | 2024-03-09T21:33:27Z |
| format | Article |
| id | doaj.art-815e73f486ae49d8a877b1e4ac306d79 |
| institution | Directory Open Access Journal |
| issn | 2312-7481 |
| language | English |
| last_indexed | 2024-03-09T21:33:27Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj.art-815e73f486ae49d8a877b1e4ac306d792023-11-23T20:49:15ZengMDPI AGMagnetochemistry2312-74812022-01-01821310.3390/magnetochemistry8020013Serum Albumin for Magnetic Nanoparticles CoatingAlexey S. Chubarov0Institute of Chemical Biology and Fundamental Medicine, SB RAS, 630090 Novosibirsk, RussiaMagnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. However, colloidal stability, biocompatibility, and potential toxicity of MNPs in physiological environments are crucial for their in vivo application. In this context, many research articles focused on the possible procedures for MNPs coating to improve their physic-chemical and biological properties. This review highlights one viable fabrication strategy of biocompatible iron oxide nanoparticles using human serum albumin (HSA). HSA is mainly a transport protein with many functions in various fundamental processes. As it is one of the most abundant plasma proteins, not a single drug in the blood passes without its strength test. It influences the stability, pharmacokinetics, and biodistribution of different drug-delivery systems by binding or forming its protein corona on the surface. The development of albumin-based drug carriers is gaining increasing importance in the targeted delivery of cancer therapy. Considering this, HSA is a highly potential candidate for nanoparticles coating and theranostics area and can provide biocompatibility, prolonged blood circulation, and possibly resolve the drug-resistance cancer problem.https://www.mdpi.com/2312-7481/8/2/13iron oxide nanoparticlesfunctionalizationcoatingserum albumindrug deliverytoxicity |
| spellingShingle | Alexey S. Chubarov Serum Albumin for Magnetic Nanoparticles Coating Magnetochemistry iron oxide nanoparticles functionalization coating serum albumin drug delivery toxicity |
| title | Serum Albumin for Magnetic Nanoparticles Coating |
| title_full | Serum Albumin for Magnetic Nanoparticles Coating |
| title_fullStr | Serum Albumin for Magnetic Nanoparticles Coating |
| title_full_unstemmed | Serum Albumin for Magnetic Nanoparticles Coating |
| title_short | Serum Albumin for Magnetic Nanoparticles Coating |
| title_sort | serum albumin for magnetic nanoparticles coating |
| topic | iron oxide nanoparticles functionalization coating serum albumin drug delivery toxicity |
| url | https://www.mdpi.com/2312-7481/8/2/13 |
| work_keys_str_mv | AT alexeyschubarov serumalbuminformagneticnanoparticlescoating |