Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update
Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients. Quercetin is a flavonol present in fruits, vegetables, and Traditional Chinese...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.865376/full |
| _version_ | 1818366614539599872 |
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| author | Shen Chen Shen Chen Yueheng Tang Yang Gao Kexin Nie Hongzhan Wang Hao Su Zhi Wang Fuer Lu Wenya Huang Hui Dong |
| author_facet | Shen Chen Shen Chen Yueheng Tang Yang Gao Kexin Nie Hongzhan Wang Hao Su Zhi Wang Fuer Lu Wenya Huang Hui Dong |
| author_sort | Shen Chen |
| collection | DOAJ |
| description | Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients. Quercetin is a flavonol present in fruits, vegetables, and Traditional Chinese medicine (TCM) that has been proved to have various pharmacological effects such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, and neuroprotective. This review summarizes the evidence for the pharmacological application of quercetin to treat depression. We clarified the mechanisms of quercetin regulating the levels of neurotransmitters, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and reducing inflammatory states and anti-oxidative stress. We also summarized the antidepressant effects of some quercetin glycoside derivatives to provide a reference for further research and clinical application. |
| first_indexed | 2024-12-13T22:38:58Z |
| format | Article |
| id | doaj.art-815f6e0cda1346c5b07b5e2c654401e9 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T22:38:58Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-815f6e0cda1346c5b07b5e2c654401e92022-12-21T23:28:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.865376865376Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and UpdateShen Chen0Shen Chen1Yueheng Tang2Yang Gao3Kexin Nie4Hongzhan Wang5Hao Su6Zhi Wang7Fuer Lu8Wenya Huang9Hui Dong10Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaGrade 2017 of Integrated Traditional Chinese and Western Clinical Medicine, Second Clinical School, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients. Quercetin is a flavonol present in fruits, vegetables, and Traditional Chinese medicine (TCM) that has been proved to have various pharmacological effects such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, and neuroprotective. This review summarizes the evidence for the pharmacological application of quercetin to treat depression. We clarified the mechanisms of quercetin regulating the levels of neurotransmitters, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and reducing inflammatory states and anti-oxidative stress. We also summarized the antidepressant effects of some quercetin glycoside derivatives to provide a reference for further research and clinical application.https://www.frontiersin.org/articles/10.3389/fphar.2022.865376/fullquercetinantidepressantglycoside derivativesisoquercetinhyperinrutin |
| spellingShingle | Shen Chen Shen Chen Yueheng Tang Yang Gao Kexin Nie Hongzhan Wang Hao Su Zhi Wang Fuer Lu Wenya Huang Hui Dong Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update Frontiers in Pharmacology quercetin antidepressant glycoside derivatives isoquercetin hyperin rutin |
| title | Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update |
| title_full | Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update |
| title_fullStr | Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update |
| title_full_unstemmed | Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update |
| title_short | Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update |
| title_sort | antidepressant potential of quercetin and its glycoside derivatives a comprehensive review and update |
| topic | quercetin antidepressant glycoside derivatives isoquercetin hyperin rutin |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.865376/full |
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