A test of the pioneer factor hypothesis using ectopic liver gene activation

A test of the pioneer factor hypothesis using ectopic liver gene activation

The pioneer factor hypothesis (PFH) states that pioneer factors (PFs) are a subclass of transcription factors (TFs) that bind to and open inaccessible sites and then recruit non-pioneer factors (non-PFs) that activate batteries of silent genes. The PFH predicts that ectopic gene activation requires...

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Bibliographic Details
Main Authors: Jeffrey L Hansen, Kaiser J Loell, Barak A Cohen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
human k562 cell line
pioneer factors
transcription factors
gene expression
cellular reprogramming
Online Access:https://elifesciences.org/articles/73358

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