Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer
Kuang He, Wen-Juan Gan Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wen-Juan Gan, Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, 215124, People’s Republic of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-05-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/wnt-catenin-signaling-pathway-in-the-development-and-progression-of-co-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1797821708265062400 |
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| author | He K Gan WJ |
| author_facet | He K Gan WJ |
| author_sort | He K |
| collection | DOAJ |
| description | Kuang He, Wen-Juan Gan Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wen-Juan Gan, Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, 215124, People’s Republic of China, Tel +86 0512-65955080, Email ganwenjuan@suda.edu.cnAbstract: The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.Keywords: Wnt pathway, colorectal carcinogenesis, APC, CRC therapy |
| first_indexed | 2024-03-13T09:56:45Z |
| format | Article |
| id | doaj.art-81625a901b5f4ff98c549b04a8813c68 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-03-13T09:56:45Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-81625a901b5f4ff98c549b04a8813c682023-05-23T18:52:22ZengDove Medical PressCancer Management and Research1179-13222023-05-01Volume 1543544883923Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal CancerHe KGan WJKuang He, Wen-Juan Gan Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wen-Juan Gan, Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, 215124, People’s Republic of China, Tel +86 0512-65955080, Email ganwenjuan@suda.edu.cnAbstract: The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.Keywords: Wnt pathway, colorectal carcinogenesis, APC, CRC therapyhttps://www.dovepress.com/wnt-catenin-signaling-pathway-in-the-development-and-progression-of-co-peer-reviewed-fulltext-article-CMARwnt pathwaycolorectal carcinogenesisapccrc therapy |
| spellingShingle | He K Gan WJ Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer Cancer Management and Research wnt pathway colorectal carcinogenesis apc crc therapy |
| title | Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer |
| title_full | Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer |
| title_fullStr | Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer |
| title_full_unstemmed | Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer |
| title_short | Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer |
| title_sort | wnt beta catenin signaling pathway in the development and progression of colorectal cancer |
| topic | wnt pathway colorectal carcinogenesis apc crc therapy |
| url | https://www.dovepress.com/wnt-catenin-signaling-pathway-in-the-development-and-progression-of-co-peer-reviewed-fulltext-article-CMAR |
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