Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks
Ghrelin, a novel growth hormone (GH)-releasing acylated peptide, is recently isolated from rat stomach. This peptide stimulates the release of GH from the anterior pituitary through the GH secretagogue receptor and feeding in the rat. However, intracerebroventricular (ICV) injection of rat ghrelin i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Poultry Science Association
2001-10-01
|
| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/38/4/38_4_358/_pdf/-char/en |
| _version_ | 1797817067392466944 |
|---|---|
| author | Tetsuya Tachibana Atsushi Ohgushi Mitsuhiro Furuse |
| author_facet | Tetsuya Tachibana Atsushi Ohgushi Mitsuhiro Furuse |
| author_sort | Tetsuya Tachibana |
| collection | DOAJ |
| description | Ghrelin, a novel growth hormone (GH)-releasing acylated peptide, is recently isolated from rat stomach. This peptide stimulates the release of GH from the anterior pituitary through the GH secretagogue receptor and feeding in the rat. However, intracerebroventricular (ICV) injection of rat ghrelin inhibited feeding of chicks under both ad libitum feeding and fasting conditions (Furuse et al., 2001). Thus, we have investigated the behavioral changes by ghrelin with special reference to sleep-like behavior of the neonatal chick in two experiments. Four behavioral categories were distinguished and scored as follows: 1, standing with eyes open; 2, sitting with eyes open; 3, standing with eyes closed; and 4, sitting motionless with head drooped (sleeping posture). Firstly, ICV injection of 0, 1.25, 2.5 and 5μg of ghrelin was done to ad libitum fed birds. Secondly, several doses (0, 0.5, 1 and 2μg) of ghrelin were injected ICV into chicks previously deprived of food for 3h. In both experiments, scores of ghrelin treated birds were higher than those of control birds. These results suggest that one of the central roles of ghrelin in the neonatal chick is induction of sleep. |
| first_indexed | 2024-03-13T08:47:07Z |
| format | Article |
| id | doaj.art-81632b10c09842cea100044c0253a3d5 |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:47:07Z |
| publishDate | 2001-10-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-81632b10c09842cea100044c0253a3d52023-05-30T00:25:17ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862001-10-0138435836310.2141/jpsa.38.358jpsaIntracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal ChicksTetsuya Tachibana0Atsushi Ohgushi1Mitsuhiro Furuse2United Graduate School of Agriculture, Tokyo University of Agriculture and TechnologyLaboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu UniversityLaboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu UniversityGhrelin, a novel growth hormone (GH)-releasing acylated peptide, is recently isolated from rat stomach. This peptide stimulates the release of GH from the anterior pituitary through the GH secretagogue receptor and feeding in the rat. However, intracerebroventricular (ICV) injection of rat ghrelin inhibited feeding of chicks under both ad libitum feeding and fasting conditions (Furuse et al., 2001). Thus, we have investigated the behavioral changes by ghrelin with special reference to sleep-like behavior of the neonatal chick in two experiments. Four behavioral categories were distinguished and scored as follows: 1, standing with eyes open; 2, sitting with eyes open; 3, standing with eyes closed; and 4, sitting motionless with head drooped (sleeping posture). Firstly, ICV injection of 0, 1.25, 2.5 and 5μg of ghrelin was done to ad libitum fed birds. Secondly, several doses (0, 0.5, 1 and 2μg) of ghrelin were injected ICV into chicks previously deprived of food for 3h. In both experiments, scores of ghrelin treated birds were higher than those of control birds. These results suggest that one of the central roles of ghrelin in the neonatal chick is induction of sleep.https://www.jstage.jst.go.jp/article/jpsa/38/4/38_4_358/_pdf/-char/enghrelinintracerebroventricularsleep-like behaviorchick |
| spellingShingle | Tetsuya Tachibana Atsushi Ohgushi Mitsuhiro Furuse Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks The Journal of Poultry Science ghrelin intracerebroventricular sleep-like behavior chick |
| title | Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks |
| title_full | Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks |
| title_fullStr | Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks |
| title_full_unstemmed | Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks |
| title_short | Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks |
| title_sort | intracerebroventricular injection of ghrelin induces sleep like behavior in neonatal chicks |
| topic | ghrelin intracerebroventricular sleep-like behavior chick |
| url | https://www.jstage.jst.go.jp/article/jpsa/38/4/38_4_358/_pdf/-char/en |
| work_keys_str_mv | AT tetsuyatachibana intracerebroventricularinjectionofghrelininducessleeplikebehaviorinneonatalchicks AT atsushiohgushi intracerebroventricularinjectionofghrelininducessleeplikebehaviorinneonatalchicks AT mitsuhirofuruse intracerebroventricularinjectionofghrelininducessleeplikebehaviorinneonatalchicks |