Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway
We sought to investigate the effect of rose petal extract (RPE) on the proliferation, migration, and invasion of cancer cells. RPE significantly inhibited the growth of lung and colorectal cancer cell lines, with rapid suppression of A549 lung cancer cells at low concentrations. These effects occurr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5119 |
| _version_ | 1797548887034036224 |
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| author | Won-Chul Lim Hyo-Kyung Choi Kyung-Tack Kim Tae-Gyu Lim |
| author_facet | Won-Chul Lim Hyo-Kyung Choi Kyung-Tack Kim Tae-Gyu Lim |
| author_sort | Won-Chul Lim |
| collection | DOAJ |
| description | We sought to investigate the effect of rose petal extract (RPE) on the proliferation, migration, and invasion of cancer cells. RPE significantly inhibited the growth of lung and colorectal cancer cell lines, with rapid suppression of A549 lung cancer cells at low concentrations. These effects occurred concomitantly with downregulation of the cell proliferation mediators PCNA, cyclin D1, and c-myc. In addition, RPE suppressed the migration and invasion of A549 cells by inhibiting the expression and activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and -9). We hypothesize that the suppressive activity of RPE against lung cancer cell proliferation and early metastasis occurs via the EGFR-MAPK and mTOR-Akt signaling pathways. These early results highlight the significant potency of RPE, particularly for lung cancer cells, and warrant further investigation. |
| first_indexed | 2024-03-10T15:06:11Z |
| format | Article |
| id | doaj.art-81655441f25d4f4c946b63c9dd8e5649 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:06:11Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-81655441f25d4f4c946b63c9dd8e56492023-11-20T19:43:16ZengMDPI AGMolecules1420-30492020-11-012521511910.3390/molecules25215119Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling PathwayWon-Chul Lim0Hyo-Kyung Choi1Kyung-Tack Kim2Tae-Gyu Lim3Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, KoreaKorea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, KoreaKorea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, KoreaKorea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, KoreaWe sought to investigate the effect of rose petal extract (RPE) on the proliferation, migration, and invasion of cancer cells. RPE significantly inhibited the growth of lung and colorectal cancer cell lines, with rapid suppression of A549 lung cancer cells at low concentrations. These effects occurred concomitantly with downregulation of the cell proliferation mediators PCNA, cyclin D1, and c-myc. In addition, RPE suppressed the migration and invasion of A549 cells by inhibiting the expression and activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and -9). We hypothesize that the suppressive activity of RPE against lung cancer cell proliferation and early metastasis occurs via the EGFR-MAPK and mTOR-Akt signaling pathways. These early results highlight the significant potency of RPE, particularly for lung cancer cells, and warrant further investigation.https://www.mdpi.com/1420-3049/25/21/5119anticancerinvasionmigrationphytochemicalsproliferationrose petal extract |
| spellingShingle | Won-Chul Lim Hyo-Kyung Choi Kyung-Tack Kim Tae-Gyu Lim Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway Molecules anticancer invasion migration phytochemicals proliferation rose petal extract |
| title | Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway |
| title_full | Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway |
| title_fullStr | Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway |
| title_full_unstemmed | Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway |
| title_short | Rose (<i>Rosa gallica</i>) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway |
| title_sort | rose i rosa gallica i petal extract suppress proliferation migration and invasion of human lung adenocarcinoma a549 cells through via the egfr signaling pathway |
| topic | anticancer invasion migration phytochemicals proliferation rose petal extract |
| url | https://www.mdpi.com/1420-3049/25/21/5119 |
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