Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel
Daphné Denis,1 Nathalie Beneton,1 Kamel Laribi,2 Hervé Maillard1 1Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France; 2Haematology Department, Centre Hospitalier Le Mans, Le Mans, France Abstract: Mycosis fungoides (MF) is a low-grade cutaneous lymphoma account...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-03-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/management-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-mf-ctcl-peer-reviewed-article-CMAR |
| _version_ | 1811266227889242112 |
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| author | Denis D Beneton N Laribi K Maillard H |
| author_facet | Denis D Beneton N Laribi K Maillard H |
| author_sort | Denis D |
| collection | DOAJ |
| description | Daphné Denis,1 Nathalie Beneton,1 Kamel Laribi,2 Hervé Maillard1 1Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France; 2Haematology Department, Centre Hospitalier Le Mans, Le Mans, France Abstract: Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, randomized studies are lacking, and treatment is based mainly on the recent published European Organisation for Research and Treatment of Cancer guidelines. Basically, early-stage MF is treated with skin-directed treatments, whereas advanced-stage MF requires more aggressive therapies. Among the skin-directed therapies, nitrogen mustard has been used for more than 50 years. A gel formulation was developed recently, showing a slight decrease in efficacy, counterbalanced by better tolerance (essentially due to a decrease in delayed hypersensitivity reactions). This review aims to summarize the current management of MF and the role of chlormethine gel in the treatment of the disease. Keywords: mycosis fungoides, nitrogen mustard, mechlorethamine, chlormethine, gel
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| first_indexed | 2024-04-12T20:39:30Z |
| format | Article |
| id | doaj.art-8165b98eb17a4467a5feea365e8e4131 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-12T20:39:30Z |
| publishDate | 2019-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-8165b98eb17a4467a5feea365e8e41312022-12-22T03:17:28ZengDove Medical PressCancer Management and Research1179-13222019-03-01Volume 112241225144652Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gelDenis DBeneton NLaribi KMaillard HDaphné Denis,1 Nathalie Beneton,1 Kamel Laribi,2 Hervé Maillard1 1Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France; 2Haematology Department, Centre Hospitalier Le Mans, Le Mans, France Abstract: Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, randomized studies are lacking, and treatment is based mainly on the recent published European Organisation for Research and Treatment of Cancer guidelines. Basically, early-stage MF is treated with skin-directed treatments, whereas advanced-stage MF requires more aggressive therapies. Among the skin-directed therapies, nitrogen mustard has been used for more than 50 years. A gel formulation was developed recently, showing a slight decrease in efficacy, counterbalanced by better tolerance (essentially due to a decrease in delayed hypersensitivity reactions). This review aims to summarize the current management of MF and the role of chlormethine gel in the treatment of the disease. Keywords: mycosis fungoides, nitrogen mustard, mechlorethamine, chlormethine, gel https://www.dovepress.com/management-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-mf-ctcl-peer-reviewed-article-CMARmycosis fungoidesnitrogen mustardmechlorethaminechlormethinegel |
| spellingShingle | Denis D Beneton N Laribi K Maillard H Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel Cancer Management and Research mycosis fungoides nitrogen mustard mechlorethamine chlormethine gel |
| title | Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel |
| title_full | Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel |
| title_fullStr | Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel |
| title_full_unstemmed | Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel |
| title_short | Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel |
| title_sort | management of mycosis fungoides type cutaneous t cell lymphoma mf ctcl focus on chlormethine gel |
| topic | mycosis fungoides nitrogen mustard mechlorethamine chlormethine gel |
| url | https://www.dovepress.com/management-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-mf-ctcl-peer-reviewed-article-CMAR |
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