New Derivatives of Lupeol and Their Biological Activity
The natural product lupeol (<b>1</b>) was isolated from <i>Bombax ceiba</i> leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (<b>2a</b>, <b>2b</b>, and <b>3</b>) were synthesized using oxidat...
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| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2021/4/M1306 |
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| author | Hoang-Thuy-Tien Le Quoc-Cuong Chau Thuc-Huy Duong Quyen-Thien-Phuc Tran Nguyen-Kim-Tuyen Pham Thi-Hoai-Thu Nguyen Ngoc-Hong Nguyen Jirapast Sichaem |
| author_facet | Hoang-Thuy-Tien Le Quoc-Cuong Chau Thuc-Huy Duong Quyen-Thien-Phuc Tran Nguyen-Kim-Tuyen Pham Thi-Hoai-Thu Nguyen Ngoc-Hong Nguyen Jirapast Sichaem |
| author_sort | Hoang-Thuy-Tien Le |
| collection | DOAJ |
| description | The natural product lupeol (<b>1</b>) was isolated from <i>Bombax ceiba</i> leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (<b>2a</b>, <b>2b</b>, and <b>3</b>) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds <b>3</b> showed significant <i>α</i>-glucosidase inhibition with an IC<sub>50</sub> value of 202 µM, whereas <b>2a</b> and <b>2b</b> were inactive. |
| first_indexed | 2024-03-10T03:30:19Z |
| format | Article |
| id | doaj.art-8165e72be7ed4f3984d66b196435a0cd |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T03:30:19Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-8165e72be7ed4f3984d66b196435a0cd2023-11-23T09:43:40ZengMDPI AGMolbank1422-85992021-12-0120214M130610.3390/M1306New Derivatives of Lupeol and Their Biological ActivityHoang-Thuy-Tien Le0Quoc-Cuong Chau1Thuc-Huy Duong2Quyen-Thien-Phuc Tran3Nguyen-Kim-Tuyen Pham4Thi-Hoai-Thu Nguyen5Ngoc-Hong Nguyen6Jirapast Sichaem7Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, VietnamDepartment of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, VietnamDepartment of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, VietnamDepartment of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, VietnamFaculty of Environmental Science, Sai Gon University, Ho Chi Minh City 72711, VietnamFaculty of Basic Sciences, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, Dist. 5, Ho Chi Minh City 700000, VietnamCirTech Institute, HUTECT University, Ho Chi Minh City 72324, VietnamResearch Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, ThailandThe natural product lupeol (<b>1</b>) was isolated from <i>Bombax ceiba</i> leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (<b>2a</b>, <b>2b</b>, and <b>3</b>) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds <b>3</b> showed significant <i>α</i>-glucosidase inhibition with an IC<sub>50</sub> value of 202 µM, whereas <b>2a</b> and <b>2b</b> were inactive.https://www.mdpi.com/1422-8599/2021/4/M1306lupeol derivativebenzylidene derivative<i>α</i>-glucosidase inhibitionOxone<sup>®</sup> |
| spellingShingle | Hoang-Thuy-Tien Le Quoc-Cuong Chau Thuc-Huy Duong Quyen-Thien-Phuc Tran Nguyen-Kim-Tuyen Pham Thi-Hoai-Thu Nguyen Ngoc-Hong Nguyen Jirapast Sichaem New Derivatives of Lupeol and Their Biological Activity Molbank lupeol derivative benzylidene derivative <i>α</i>-glucosidase inhibition Oxone<sup>®</sup> |
| title | New Derivatives of Lupeol and Their Biological Activity |
| title_full | New Derivatives of Lupeol and Their Biological Activity |
| title_fullStr | New Derivatives of Lupeol and Their Biological Activity |
| title_full_unstemmed | New Derivatives of Lupeol and Their Biological Activity |
| title_short | New Derivatives of Lupeol and Their Biological Activity |
| title_sort | new derivatives of lupeol and their biological activity |
| topic | lupeol derivative benzylidene derivative <i>α</i>-glucosidase inhibition Oxone<sup>®</sup> |
| url | https://www.mdpi.com/1422-8599/2021/4/M1306 |
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