KRAS Gene Mutations and Gender Differences in Colorectal Cancer
The aim of this study was to investigate the frequency and spectrum of KRAS mutations in men and women with colorectal cancer (CRC), and an impact of KRAS-mutation status on the clinical and morphological features of CRC. The study included 303 patients (168/55.4% women and 135/44.6% men) with CRC T...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2015-03-01
|
| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/Article5(1)_CR2.pdf |
| _version_ | 1818513016167071744 |
|---|---|
| author | Dmitriy I. Vodolazhskiy Yuriy A. Gevorkyan Natalia V. Soldatkina |
| author_facet | Dmitriy I. Vodolazhskiy Yuriy A. Gevorkyan Natalia V. Soldatkina |
| author_sort | Dmitriy I. Vodolazhskiy |
| collection | DOAJ |
| description | The aim of this study was to investigate the frequency and spectrum of KRAS mutations in men and women with colorectal cancer (CRC), and an impact of KRAS-mutation status on the clinical and morphological features of CRC. The study included 303 patients (168/55.4% women and 135/44.6% men) with CRC T2-4N0-2M0-1. We defined 7 KRAS SNP-mutations (G12D, G12A, G12R, G12C, G12S, G12V and G13D) located within codons 12 and 13 using Bio-Rad real-time thermal cyclers CFX96 and Real-Time-PCR- KRAS-7M Kit. The frequency of KRAS mutations was 35.6% in the CRC patients with a predominant presence of G>A transitions. The KRAS codon 12 and 13 mutations are predictive of poor prognosis The KRAS-mutated CRC has clinical features in view of the gender differences. KRAS-mutation status is a promising predictive biomarker of personalized treatment. |
| first_indexed | 2024-12-10T23:55:06Z |
| format | Article |
| id | doaj.art-816720e0fb2549f887040e5d97b96cb5 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-10T23:55:06Z |
| publishDate | 2015-03-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-816720e0fb2549f887040e5d97b96cb52022-12-22T01:28:37ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292015-03-01511115KRAS Gene Mutations and Gender Differences in Colorectal CancerDmitriy I. Vodolazhskiy0Yuriy A. Gevorkyan1Natalia V. Soldatkina2Federal State Budget Institution «Rostov Research Oncologic Institute»; Rostov-on-Don, the Russian FederationFederal State Budget Institution «Rostov Research Oncologic Institute»; Rostov-on-Don, the Russian FederationFederal State Budget Institution «Rostov Research Oncologic Institute»; Rostov-on-Don, the Russian FederationThe aim of this study was to investigate the frequency and spectrum of KRAS mutations in men and women with colorectal cancer (CRC), and an impact of KRAS-mutation status on the clinical and morphological features of CRC. The study included 303 patients (168/55.4% women and 135/44.6% men) with CRC T2-4N0-2M0-1. We defined 7 KRAS SNP-mutations (G12D, G12A, G12R, G12C, G12S, G12V and G13D) located within codons 12 and 13 using Bio-Rad real-time thermal cyclers CFX96 and Real-Time-PCR- KRAS-7M Kit. The frequency of KRAS mutations was 35.6% in the CRC patients with a predominant presence of G>A transitions. The KRAS codon 12 and 13 mutations are predictive of poor prognosis The KRAS-mutated CRC has clinical features in view of the gender differences. KRAS-mutation status is a promising predictive biomarker of personalized treatment.http://ijbm.org/articles/Article5(1)_CR2.pdfKRAS codon 12 and 13 mutations;colorectal cancer;gender differences. |
| spellingShingle | Dmitriy I. Vodolazhskiy Yuriy A. Gevorkyan Natalia V. Soldatkina KRAS Gene Mutations and Gender Differences in Colorectal Cancer International Journal of Biomedicine KRAS codon 12 and 13 mutations; colorectal cancer; gender differences. |
| title | KRAS Gene Mutations and Gender Differences in Colorectal Cancer |
| title_full | KRAS Gene Mutations and Gender Differences in Colorectal Cancer |
| title_fullStr | KRAS Gene Mutations and Gender Differences in Colorectal Cancer |
| title_full_unstemmed | KRAS Gene Mutations and Gender Differences in Colorectal Cancer |
| title_short | KRAS Gene Mutations and Gender Differences in Colorectal Cancer |
| title_sort | kras gene mutations and gender differences in colorectal cancer |
| topic | KRAS codon 12 and 13 mutations; colorectal cancer; gender differences. |
| url | http://ijbm.org/articles/Article5(1)_CR2.pdf |
| work_keys_str_mv | AT dmitriyivodolazhskiy krasgenemutationsandgenderdifferencesincolorectalcancer AT yuriyagevorkyan krasgenemutationsandgenderdifferencesincolorectalcancer AT nataliavsoldatkina krasgenemutationsandgenderdifferencesincolorectalcancer |