Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands
<p>Abstract</p> <p>Background</p> <p>Q fever has become a major public health problem in the Netherlands. Infection with <it>Coxiella burnetii </it>(Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases. Theref...
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| Format: | Article |
| Language: | English |
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BMC
2011-02-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/11/44 |
| _version_ | 1811267134804721664 |
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| author | Notermans Daan W Wijers Nancy Leenders Alexander CAP Meekelenkamp Jamie CE van der Hoek Wim Hukkelhoven Chantal WPM |
| author_facet | Notermans Daan W Wijers Nancy Leenders Alexander CAP Meekelenkamp Jamie CE van der Hoek Wim Hukkelhoven Chantal WPM |
| author_sort | Notermans Daan W |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Q fever has become a major public health problem in the Netherlands. Infection with <it>Coxiella burnetii </it>(Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases. Therefore, we aimed to quantify this risk by examining the earliest periods corresponding to the epidemic in the Netherlands.</p> <p>Methods</p> <p>Serum samples that had been collected from the area of highest incidence by an existing national prenatal screening programme and data from the Netherlands Perinatal Registry (PRN) on diagnosis and outcome were used. We performed indirect immunofluorescence assay to detect the presence of IgM and IgG antibodies against <it>C. burnetii </it>in the samples. The serological results were analyzed to determine statistical association with recorded pregnancy outcome.</p> <p>Results</p> <p>Evaluation of serological results for 1174 women in the PRN indicated that the presence of IgM and IgG antibodies against phase II of <it>C. burnetii </it>was not significantly associated with preterm delivery, low birth weight, or several other outcome measures.</p> <p>Conclusion</p> <p>The present population-based study showed no evidence of adverse pregnancy outcome among women who had antibodies to <it>C. burnetii </it>during early pregnancy.</p> |
| first_indexed | 2024-04-12T20:57:03Z |
| format | Article |
| id | doaj.art-8169b3fa4e5b491b95bb3add367aac0b |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T20:57:03Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-8169b3fa4e5b491b95bb3add367aac0b2022-12-22T03:16:57ZengBMCBMC Infectious Diseases1471-23342011-02-011114410.1186/1471-2334-11-44Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the NetherlandsNotermans Daan WWijers NancyLeenders Alexander CAPMeekelenkamp Jamie CEvan der Hoek WimHukkelhoven Chantal WPM<p>Abstract</p> <p>Background</p> <p>Q fever has become a major public health problem in the Netherlands. Infection with <it>Coxiella burnetii </it>(Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases. Therefore, we aimed to quantify this risk by examining the earliest periods corresponding to the epidemic in the Netherlands.</p> <p>Methods</p> <p>Serum samples that had been collected from the area of highest incidence by an existing national prenatal screening programme and data from the Netherlands Perinatal Registry (PRN) on diagnosis and outcome were used. We performed indirect immunofluorescence assay to detect the presence of IgM and IgG antibodies against <it>C. burnetii </it>in the samples. The serological results were analyzed to determine statistical association with recorded pregnancy outcome.</p> <p>Results</p> <p>Evaluation of serological results for 1174 women in the PRN indicated that the presence of IgM and IgG antibodies against phase II of <it>C. burnetii </it>was not significantly associated with preterm delivery, low birth weight, or several other outcome measures.</p> <p>Conclusion</p> <p>The present population-based study showed no evidence of adverse pregnancy outcome among women who had antibodies to <it>C. burnetii </it>during early pregnancy.</p>http://www.biomedcentral.com/1471-2334/11/44 |
| spellingShingle | Notermans Daan W Wijers Nancy Leenders Alexander CAP Meekelenkamp Jamie CE van der Hoek Wim Hukkelhoven Chantal WPM Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands BMC Infectious Diseases |
| title | Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands |
| title_full | Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands |
| title_fullStr | Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands |
| title_full_unstemmed | Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands |
| title_short | Antibodies against <it>Coxiella burnetii </it>and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Netherlands |
| title_sort | antibodies against it coxiella burnetii it and pregnancy outcome during the 2007 2008 q fever outbreaks in the netherlands |
| url | http://www.biomedcentral.com/1471-2334/11/44 |
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