Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis
Skin infiltration of circulating memory T cells with cutaneous tropism is considered one of the pathologic mechanisms in atopic dermatitis (AD). Skin-seeking circulating T lymphocytes can be identified by their expression of the cutaneous lymphocyte-associated antigen on the cell surface. Recent stu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2010-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119304715 |
| _version_ | 1819266167247732736 |
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| author | Marta Ferran, MD Luis F Santamaria-Babi, PhD |
| author_facet | Marta Ferran, MD Luis F Santamaria-Babi, PhD |
| author_sort | Marta Ferran, MD |
| collection | DOAJ |
| description | Skin infiltration of circulating memory T cells with cutaneous tropism is considered one of the pathologic mechanisms in atopic dermatitis (AD). Skin-seeking circulating T lymphocytes can be identified by their expression of the cutaneous lymphocyte-associated antigen on the cell surface. Recent studies have contributed useful new information about the function and recirculation properties of those cells in AD patients. This review integrates the latest findings on peripheral cutaneous lymphocyte-associated antigen memory T cells in AD and highlights the relevance of this cell type and its importance to our understanding of the pathologic mechanisms of AD. Keywords: homing, CLA, skin, atopic eczema, T cell |
| first_indexed | 2024-12-23T20:56:58Z |
| format | Article |
| id | doaj.art-816dc049d8a04e86b3a39944a9daf4b8 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-23T20:56:58Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-816dc049d8a04e86b3a39944a9daf4b82022-12-21T17:31:29ZengElsevierWorld Allergy Organization Journal1939-45512010-01-01334447Pathological Mechanisms of Skin Homing T Cells in Atopic DermatitisMarta Ferran, MD0Luis F Santamaria-Babi, PhD1Department of Dermatology, Hospital del Mar, IMAS-IMIM, Barcelona, SpainDepartment of Dermatology, Hospital del Mar, IMAS-IMIM, Barcelona, Spain; Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain; Corresponding author.Skin infiltration of circulating memory T cells with cutaneous tropism is considered one of the pathologic mechanisms in atopic dermatitis (AD). Skin-seeking circulating T lymphocytes can be identified by their expression of the cutaneous lymphocyte-associated antigen on the cell surface. Recent studies have contributed useful new information about the function and recirculation properties of those cells in AD patients. This review integrates the latest findings on peripheral cutaneous lymphocyte-associated antigen memory T cells in AD and highlights the relevance of this cell type and its importance to our understanding of the pathologic mechanisms of AD. Keywords: homing, CLA, skin, atopic eczema, T cellhttp://www.sciencedirect.com/science/article/pii/S1939455119304715 |
| spellingShingle | Marta Ferran, MD Luis F Santamaria-Babi, PhD Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis World Allergy Organization Journal |
| title | Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis |
| title_full | Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis |
| title_fullStr | Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis |
| title_full_unstemmed | Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis |
| title_short | Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis |
| title_sort | pathological mechanisms of skin homing t cells in atopic dermatitis |
| url | http://www.sciencedirect.com/science/article/pii/S1939455119304715 |
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