Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up
AbstractBackground This is the first study to examine the clinical utility of measuring plasma secretoneurin (SN) levels in patients with heart failure with reduced ejection fraction (HFrEF), as a predictor of unplanned hospitalization, and all-cause mortality independently, and as a composite endpo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2305309 |
| _version_ | 1827375943078903808 |
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| author | Łukasz Wołowiec Daniel Rogowicz Jacek Budzyński Joanna Banach Anna Wołowiec Mariusz Kozakiewicz Maciej Bieliński Albert Jaśniak Joanna Osiak Grzegorz Grześk |
| author_facet | Łukasz Wołowiec Daniel Rogowicz Jacek Budzyński Joanna Banach Anna Wołowiec Mariusz Kozakiewicz Maciej Bieliński Albert Jaśniak Joanna Osiak Grzegorz Grześk |
| author_sort | Łukasz Wołowiec |
| collection | DOAJ |
| description | AbstractBackground This is the first study to examine the clinical utility of measuring plasma secretoneurin (SN) levels in patients with heart failure with reduced ejection fraction (HFrEF), as a predictor of unplanned hospitalization, and all-cause mortality independently, and as a composite endpoint at one-year follow-up.Methods The study group includes 124 caucasian patients in New York Heart Association (NYHA) classes II to IV. Plasma SN concentrations were statistically analyzed in relation to sex, age, BMI, etiology of HFrEF, pharmacotherapy, clinical, laboratory and echocardiographic parameters. Samples were collected within 24 h of admission to the hospital.Key results In the 12-month follow-up, high SN levels were noted for all three endpoints.Conclusions SN positively correlates with HF severity measured by NYHA classes and proves to be a useful prognostic parameter in predicting unplanned hospitalizations and all-cause mortality among patients with HFrEF. Patients with high SN levels may benefit from systematic follow-up and may be candidates for more aggressive treatment. |
| first_indexed | 2024-03-08T12:01:40Z |
| format | Article |
| id | doaj.art-816dc786ae2a495d8ee7ad8b527c0d49 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T12:01:40Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-816dc786ae2a495d8ee7ad8b527c0d492024-01-23T18:29:08ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2305309Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-upŁukasz Wołowiec0Daniel Rogowicz1Jacek Budzyński2Joanna Banach3Anna Wołowiec4Mariusz Kozakiewicz5Maciej Bieliński6Albert Jaśniak7Joanna Osiak8Grzegorz Grześk9Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Vascular and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Geriatrics, Division of Biochemistry and Biogerontology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Geriatrics, Division of Biochemistry and Biogerontology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz, PolandDepartment of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandAbstractBackground This is the first study to examine the clinical utility of measuring plasma secretoneurin (SN) levels in patients with heart failure with reduced ejection fraction (HFrEF), as a predictor of unplanned hospitalization, and all-cause mortality independently, and as a composite endpoint at one-year follow-up.Methods The study group includes 124 caucasian patients in New York Heart Association (NYHA) classes II to IV. Plasma SN concentrations were statistically analyzed in relation to sex, age, BMI, etiology of HFrEF, pharmacotherapy, clinical, laboratory and echocardiographic parameters. Samples were collected within 24 h of admission to the hospital.Key results In the 12-month follow-up, high SN levels were noted for all three endpoints.Conclusions SN positively correlates with HF severity measured by NYHA classes and proves to be a useful prognostic parameter in predicting unplanned hospitalizations and all-cause mortality among patients with HFrEF. Patients with high SN levels may benefit from systematic follow-up and may be candidates for more aggressive treatment.https://www.tandfonline.com/doi/10.1080/07853890.2024.2305309Secretoneurinheart failureHFrEFbiomarkercardiovascular system |
| spellingShingle | Łukasz Wołowiec Daniel Rogowicz Jacek Budzyński Joanna Banach Anna Wołowiec Mariusz Kozakiewicz Maciej Bieliński Albert Jaśniak Joanna Osiak Grzegorz Grześk Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up Annals of Medicine Secretoneurin heart failure HFrEF biomarker cardiovascular system |
| title | Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up |
| title_full | Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up |
| title_fullStr | Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up |
| title_full_unstemmed | Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up |
| title_short | Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up |
| title_sort | prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one year follow up |
| topic | Secretoneurin heart failure HFrEF biomarker cardiovascular system |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2305309 |
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