Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo
<p>Abstract</p> <p>Background</p> <p>Overexpression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is commonly occurred in cancers and causes radioresistance and poor prognosis. In present study, the single-chain variable antibody fragments (scFv) targetin...
Main Authors: | Du Li, Zhou Li-Jun, Pan Xiu-Jie, Wang Yu-Xiao, Xu Qin-Zhi, Yang Zhi-Hua, Wang Yu, Liu Xiao-Dan, Zhu Mao-Xiang, Zhou Ping-Kun |
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Format: | Article |
Language: | English |
Published: |
BMC
2010-08-01
|
Series: | Radiation Oncology |
Online Access: | http://www.ro-journal.com/content/5/1/70 |
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