Toxic epidermal necrolysis induced by lamotrigine treatment in a child
Toxic epidermal necrolysis is an unpredictable and severe adverse drug reaction. In toxic epidermal necrolysis, epidermal damage appears to result from keratinocyte apoptosis. This condition is triggered by many factors, principally drugs such as antiepileptic medications, antibiotics (particularly...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2014-03-01
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| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-57-153.pdf |
| _version_ | 1818552134592888832 |
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| author | Youngsuk Yi Jeong Ho Lee Eun Sook Suh |
| author_facet | Youngsuk Yi Jeong Ho Lee Eun Sook Suh |
| author_sort | Youngsuk Yi |
| collection | DOAJ |
| description | Toxic epidermal necrolysis is an unpredictable and severe adverse drug reaction. In toxic epidermal necrolysis, epidermal damage appears to result from keratinocyte apoptosis. This condition is triggered by many factors, principally drugs such as antiepileptic medications, antibiotics (particularly sulfonamide), nonsteroidal anti-inflammatory drugs, allopurinol, and nevirapine. Lamotrigine has been reported potentially cause serious cutaneous reactions, and concomitant use of valproic acid with lamotrigine significantly increases this risk. We describe a case of an 11-year-old girl with tic and major depressive disorders who developed toxic epidermal necrolysis after treatment with lamotrigine, and who was diagnosed both clinically and pathologically. Children are more susceptible to lamotrigine-induced rash than adults, and risk of serious rash can be lessened by strict adherence to dosing guidelines. Unfortunately, in our case, the patient was administered a higher dose than the required regimen. Therefore, clinicians should strictly adhere to the dose regimen when using lamotrigine, especially in children. |
| first_indexed | 2024-12-12T09:09:14Z |
| format | Article |
| id | doaj.art-81701181fd0549f0a8fa16b72bee69b7 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-12T09:09:14Z |
| publishDate | 2014-03-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-81701181fd0549f0a8fa16b72bee69b72022-12-22T00:29:35ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582014-03-0157315315610.3345/kjp.2014.57.3.1532013600038Toxic epidermal necrolysis induced by lamotrigine treatment in a childYoungsuk Yi0Jeong Ho Lee1Eun Sook Suh2Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.Toxic epidermal necrolysis is an unpredictable and severe adverse drug reaction. In toxic epidermal necrolysis, epidermal damage appears to result from keratinocyte apoptosis. This condition is triggered by many factors, principally drugs such as antiepileptic medications, antibiotics (particularly sulfonamide), nonsteroidal anti-inflammatory drugs, allopurinol, and nevirapine. Lamotrigine has been reported potentially cause serious cutaneous reactions, and concomitant use of valproic acid with lamotrigine significantly increases this risk. We describe a case of an 11-year-old girl with tic and major depressive disorders who developed toxic epidermal necrolysis after treatment with lamotrigine, and who was diagnosed both clinically and pathologically. Children are more susceptible to lamotrigine-induced rash than adults, and risk of serious rash can be lessened by strict adherence to dosing guidelines. Unfortunately, in our case, the patient was administered a higher dose than the required regimen. Therefore, clinicians should strictly adhere to the dose regimen when using lamotrigine, especially in children.http://kjp.or.kr/upload/pdf/kjped-57-153.pdfToxic epidermal necrolysisAdverse drug reactionLamotrigineAntiepileptic drug |
| spellingShingle | Youngsuk Yi Jeong Ho Lee Eun Sook Suh Toxic epidermal necrolysis induced by lamotrigine treatment in a child Korean Journal of Pediatrics Toxic epidermal necrolysis Adverse drug reaction Lamotrigine Antiepileptic drug |
| title | Toxic epidermal necrolysis induced by lamotrigine treatment in a child |
| title_full | Toxic epidermal necrolysis induced by lamotrigine treatment in a child |
| title_fullStr | Toxic epidermal necrolysis induced by lamotrigine treatment in a child |
| title_full_unstemmed | Toxic epidermal necrolysis induced by lamotrigine treatment in a child |
| title_short | Toxic epidermal necrolysis induced by lamotrigine treatment in a child |
| title_sort | toxic epidermal necrolysis induced by lamotrigine treatment in a child |
| topic | Toxic epidermal necrolysis Adverse drug reaction Lamotrigine Antiepileptic drug |
| url | http://kjp.or.kr/upload/pdf/kjped-57-153.pdf |
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