Hepcidin and iron metabolism disorders in patients with chronic kidney disease
Bacground/Aim. Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). Methods. The study involved...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2013-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501304368J.pdf |
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| author | Jelić Marija Cvetković Tatjana Đorđević Vidojko Damnjanović Goran Vlahović Predrag Kocić Gordana Đinđić Nataša Jovović Biljana Antić Ana |
| author_facet | Jelić Marija Cvetković Tatjana Đorđević Vidojko Damnjanović Goran Vlahović Predrag Kocić Gordana Đinđić Nataša Jovović Biljana Antić Ana |
| author_sort | Jelić Marija |
| collection | DOAJ |
| description | Bacground/Aim. Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). Methods. The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation. The HD group was divided in four subgroups according to the level of serum ferritin (up to 100; 100-199; 200-499 and over 500 ng/mL). Parameters of anemia, iron status, inflamation and hepcidin level were evaluated. Results. The HD patients had a significantly lower eritrocyte count, erythrocytes indexes, hemoglobin and transferrin saturation and significantly higher iron, ferritin, hepcidin and total iron binding capacity (TIBC). The HD subgroups up to 199 ng/mL of serum feritin had lower high-sensitivity Creactive protein (hsCRP), iron and higher unbuffered iron binding capacity (UIBC), transferrin saturation and TIBC compared to the HD subgroups over 200 ng/mL. The lowest and the highest ferritin subgroups had the highest hepcidin level and it showed significant correlation with ferritin. Conclusion. Hepcidin may serve as a marker for better diagnosing and monitoring anemia and iron metabolism disorders in CKD. |
| first_indexed | 2024-12-20T09:41:44Z |
| format | Article |
| id | doaj.art-8170be02e25349f993f01aee3ff3db4c |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-20T09:41:44Z |
| publishDate | 2013-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-8170be02e25349f993f01aee3ff3db4c2022-12-21T19:44:52ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502013-01-0170436837310.2298/VSP1304368JHepcidin and iron metabolism disorders in patients with chronic kidney diseaseJelić MarijaCvetković TatjanaĐorđević VidojkoDamnjanović GoranVlahović PredragKocić GordanaĐinđić NatašaJovović BiljanaAntić AnaBacground/Aim. Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). Methods. The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation. The HD group was divided in four subgroups according to the level of serum ferritin (up to 100; 100-199; 200-499 and over 500 ng/mL). Parameters of anemia, iron status, inflamation and hepcidin level were evaluated. Results. The HD patients had a significantly lower eritrocyte count, erythrocytes indexes, hemoglobin and transferrin saturation and significantly higher iron, ferritin, hepcidin and total iron binding capacity (TIBC). The HD subgroups up to 199 ng/mL of serum feritin had lower high-sensitivity Creactive protein (hsCRP), iron and higher unbuffered iron binding capacity (UIBC), transferrin saturation and TIBC compared to the HD subgroups over 200 ng/mL. The lowest and the highest ferritin subgroups had the highest hepcidin level and it showed significant correlation with ferritin. Conclusion. Hepcidin may serve as a marker for better diagnosing and monitoring anemia and iron metabolism disorders in CKD.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501304368J.pdfironferritinsanemiakidney failure, chronic |
| spellingShingle | Jelić Marija Cvetković Tatjana Đorđević Vidojko Damnjanović Goran Vlahović Predrag Kocić Gordana Đinđić Nataša Jovović Biljana Antić Ana Hepcidin and iron metabolism disorders in patients with chronic kidney disease Vojnosanitetski Pregled iron ferritins anemia kidney failure, chronic |
| title | Hepcidin and iron metabolism disorders in patients with chronic kidney disease |
| title_full | Hepcidin and iron metabolism disorders in patients with chronic kidney disease |
| title_fullStr | Hepcidin and iron metabolism disorders in patients with chronic kidney disease |
| title_full_unstemmed | Hepcidin and iron metabolism disorders in patients with chronic kidney disease |
| title_short | Hepcidin and iron metabolism disorders in patients with chronic kidney disease |
| title_sort | hepcidin and iron metabolism disorders in patients with chronic kidney disease |
| topic | iron ferritins anemia kidney failure, chronic |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501304368J.pdf |
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