The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients
Objective: Recently, the role of hepcidin as a cardiovascular marker in the chronic kidney disease (CKD) population has gained interest. The aim of this study was to investigate the relationship between serum hepcidin-25, inflammation, iron parameters, and carotid intima-media thickness (CIMT) in pe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2018-03-01
|
| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-17666 |
| _version_ | 1828024837062262784 |
|---|---|
| author | Bülent Erdoğan Barış Eser Özlem Yayar Mehmet Deniz Aylı |
| author_facet | Bülent Erdoğan Barış Eser Özlem Yayar Mehmet Deniz Aylı |
| author_sort | Bülent Erdoğan |
| collection | DOAJ |
| description | Objective: Recently, the role of hepcidin as a cardiovascular marker in the chronic kidney disease (CKD) population has gained interest. The aim of this study was to investigate the relationship between serum hepcidin-25, inflammation, iron parameters, and carotid intima-media thickness (CIMT) in peritoneal dialysis (PD) patients.
Methods: A total of 58 patients (30 male, 51.3%; mean age: 46.8+-13.6 years; mean dialysis duration: 69.2+-39.1 months) were included in this cross-sectional study. Clinical and routine laboratory data were recorded and the CIMT and hepcidin values were determined. The study population was divided into 2 groups according to the median hepcidin value of 60 ng/mL. Correlation analysis and logistic regression analysis were performed to determine the relationship between the hepcidin level and other parameters.
Results: Age (p=0.003), systolic blood pressure (p=0.039), body mass index (p=0.031), glucose (p=0.028) level, C-reactive protein (CRP) level (p<0.001), and CIMT (p=0.011) were found to be statistically significantly higher in the high hepcidin group. In correlation analysis, hepcidin was positively correlated with age (p<0.001), dialysis duration (p=0.041), glucose (p=0.015), ferritin (p=0.005), CRP (p<0.001), and CIMT (p=0.035). In multivariate linear regression analysis, age (p<0.001) and CRP (p=0.005) were found to be related to CIMT.
Conclusion: Hepcidin-25 was strongly associated with both age and CRP in patients undergoing PD treatment. The results suggest that hepcidin may be involved in the pathophysiology of atherosclerosis. Prospective studies should be carried out in this patient population to determine whether hepcidin has an effect on atherosclerosis. |
| first_indexed | 2024-04-10T12:50:34Z |
| format | Article |
| id | doaj.art-817112ff300f4f8fb5da58024660a826 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T12:50:34Z |
| publishDate | 2018-03-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-817112ff300f4f8fb5da58024660a8262023-02-15T16:13:49ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692018-03-0146212112810.5543/tkda.2017.17666TKDA-17666The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patientsBülent Erdoğan0Barış Eser1Özlem Yayar2Mehmet Deniz Aylı3Department of Nephrolgy, Yunus Emre State Hospital, Eskişehir, TurkeyDepartment of Nephrology, Hitit University, Erol Olcok Training and Research Hospital, Çorum, TurkeyDepartment of Nephrology, Çanakkale State Hospital, Çanakkale, TurkeyDepartment of Nephrology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, TurkeyObjective: Recently, the role of hepcidin as a cardiovascular marker in the chronic kidney disease (CKD) population has gained interest. The aim of this study was to investigate the relationship between serum hepcidin-25, inflammation, iron parameters, and carotid intima-media thickness (CIMT) in peritoneal dialysis (PD) patients. Methods: A total of 58 patients (30 male, 51.3%; mean age: 46.8+-13.6 years; mean dialysis duration: 69.2+-39.1 months) were included in this cross-sectional study. Clinical and routine laboratory data were recorded and the CIMT and hepcidin values were determined. The study population was divided into 2 groups according to the median hepcidin value of 60 ng/mL. Correlation analysis and logistic regression analysis were performed to determine the relationship between the hepcidin level and other parameters. Results: Age (p=0.003), systolic blood pressure (p=0.039), body mass index (p=0.031), glucose (p=0.028) level, C-reactive protein (CRP) level (p<0.001), and CIMT (p=0.011) were found to be statistically significantly higher in the high hepcidin group. In correlation analysis, hepcidin was positively correlated with age (p<0.001), dialysis duration (p=0.041), glucose (p=0.015), ferritin (p=0.005), CRP (p<0.001), and CIMT (p=0.035). In multivariate linear regression analysis, age (p<0.001) and CRP (p=0.005) were found to be related to CIMT. Conclusion: Hepcidin-25 was strongly associated with both age and CRP in patients undergoing PD treatment. The results suggest that hepcidin may be involved in the pathophysiology of atherosclerosis. Prospective studies should be carried out in this patient population to determine whether hepcidin has an effect on atherosclerosis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-17666carotid intima-media thicknesshepcidin; inflammation; peritoneal dialysis. |
| spellingShingle | Bülent Erdoğan Barış Eser Özlem Yayar Mehmet Deniz Aylı The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients Türk Kardiyoloji Derneği Arşivi carotid intima-media thickness hepcidin; inflammation; peritoneal dialysis. |
| title | The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients |
| title_full | The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients |
| title_fullStr | The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients |
| title_full_unstemmed | The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients |
| title_short | The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients |
| title_sort | association between serum hepcidin 25 level and subclinical atherosclerosis in peritoneal dialysis patients |
| topic | carotid intima-media thickness hepcidin; inflammation; peritoneal dialysis. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-17666 |
| work_keys_str_mv | AT bulenterdogan theassociationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT barıseser theassociationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT ozlemyayar theassociationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT mehmetdenizaylı theassociationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT bulenterdogan associationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT barıseser associationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT ozlemyayar associationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients AT mehmetdenizaylı associationbetweenserumhepcidin25levelandsubclinicalatherosclerosisinperitonealdialysispatients |