Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus?
Muscle cachexia is one of the most critical unmet medical needs. Identifying the molecular background of cancer-induced muscle loss revealed a promising possibility of new therapeutic targets and new drug development. In this review, we will define the signal transducer and activator of transcriptio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/21/8261 |
| _version_ | 1797548817597333504 |
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| author | Anna Jaśkiewicz Tomasz Domoradzki Beata Pająk |
| author_facet | Anna Jaśkiewicz Tomasz Domoradzki Beata Pająk |
| author_sort | Anna Jaśkiewicz |
| collection | DOAJ |
| description | Muscle cachexia is one of the most critical unmet medical needs. Identifying the molecular background of cancer-induced muscle loss revealed a promising possibility of new therapeutic targets and new drug development. In this review, we will define the signal transducer and activator of transcription 3 (STAT3) protein’s role in the tumor formation process and summarize the role of STAT3 in skeletal muscle cachexia. Finally, we will discuss a vast therapeutic potential for the STAT3-inhibiting single-agent treatment innovation that, as the desired outcome, could block tumor growth and generally prevent muscle cachexia. |
| first_indexed | 2024-03-10T15:06:12Z |
| format | Article |
| id | doaj.art-81728505a2e645b79d3f7a998d89c3a9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:06:12Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-81728505a2e645b79d3f7a998d89c3a92023-11-20T19:47:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012121826110.3390/ijms21218261Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus?Anna Jaśkiewicz0Tomasz Domoradzki1Beata Pająk2Independent Laboratory of Genetic and Molecular Biology, Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, PolandIndependent Laboratory of Genetic and Molecular Biology, Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, PolandIndependent Laboratory of Genetic and Molecular Biology, Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, PolandMuscle cachexia is one of the most critical unmet medical needs. Identifying the molecular background of cancer-induced muscle loss revealed a promising possibility of new therapeutic targets and new drug development. In this review, we will define the signal transducer and activator of transcription 3 (STAT3) protein’s role in the tumor formation process and summarize the role of STAT3 in skeletal muscle cachexia. Finally, we will discuss a vast therapeutic potential for the STAT3-inhibiting single-agent treatment innovation that, as the desired outcome, could block tumor growth and generally prevent muscle cachexia.https://www.mdpi.com/1422-0067/21/21/8261muscle cachexiatargeted therapypSTAT3 inhibitors |
| spellingShingle | Anna Jaśkiewicz Tomasz Domoradzki Beata Pająk Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus? International Journal of Molecular Sciences muscle cachexia targeted therapy pSTAT3 inhibitors |
| title | Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus? |
| title_full | Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus? |
| title_fullStr | Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus? |
| title_full_unstemmed | Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus? |
| title_short | Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus? |
| title_sort | targeting the jak2 stat3 pathway can we compare it to the two faces of the god janus |
| topic | muscle cachexia targeted therapy pSTAT3 inhibitors |
| url | https://www.mdpi.com/1422-0067/21/21/8261 |
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