Microwave Assisted Reactions of Some Azaheterocylic Compounds
A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably acc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/1/403/ |
| _version_ | 1830381025592606720 |
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| author | Gheorghita Zbancioc Vasilichia Bejan Marian Risca Costel Moldoveanu Ionel I. Mangalagiu |
| author_facet | Gheorghita Zbancioc Vasilichia Bejan Marian Risca Costel Moldoveanu Ionel I. Mangalagiu |
| author_sort | Gheorghita Zbancioc |
| collection | DOAJ |
| description | A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained. |
| first_indexed | 2024-12-20T09:41:44Z |
| format | Article |
| id | doaj.art-817346bf89e44c76b186b545b0c84aa6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T09:41:44Z |
| publishDate | 2009-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-817346bf89e44c76b186b545b0c84aa62022-12-21T19:44:52ZengMDPI AGMolecules1420-30492009-01-0114140341110.3390/molecules14010403Microwave Assisted Reactions of Some Azaheterocylic CompoundsGheorghita ZbanciocVasilichia BejanMarian RiscaCostel MoldoveanuIonel I. MangalagiuA fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.http://www.mdpi.com/1420-3049/14/1/403/Microwave N-alkylationImidazolePyrimidinePyridazinePhthalazine |
| spellingShingle | Gheorghita Zbancioc Vasilichia Bejan Marian Risca Costel Moldoveanu Ionel I. Mangalagiu Microwave Assisted Reactions of Some Azaheterocylic Compounds Molecules Microwave N-alkylation Imidazole Pyrimidine Pyridazine Phthalazine |
| title | Microwave Assisted Reactions of Some Azaheterocylic Compounds |
| title_full | Microwave Assisted Reactions of Some Azaheterocylic Compounds |
| title_fullStr | Microwave Assisted Reactions of Some Azaheterocylic Compounds |
| title_full_unstemmed | Microwave Assisted Reactions of Some Azaheterocylic Compounds |
| title_short | Microwave Assisted Reactions of Some Azaheterocylic Compounds |
| title_sort | microwave assisted reactions of some azaheterocylic compounds |
| topic | Microwave N-alkylation Imidazole Pyrimidine Pyridazine Phthalazine |
| url | http://www.mdpi.com/1420-3049/14/1/403/ |
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