Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker
Obstructive sleep apnea is one of the most common sleep disorders with a high estimated global prevalence and a large number of associated comorbidities in general as well as specific neuropsychiatric complications such as cognitive impairment. The complex pathogenesis and effects of the disorder in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1289367/full |
| _version_ | 1797435390866489344 |
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| author | Julia Jaromirska Piotr Kaczmarski Dominik Strzelecki Marcin Sochal Piotr Białasiewicz Agata Gabryelska |
| author_facet | Julia Jaromirska Piotr Kaczmarski Dominik Strzelecki Marcin Sochal Piotr Białasiewicz Agata Gabryelska |
| author_sort | Julia Jaromirska |
| collection | DOAJ |
| description | Obstructive sleep apnea is one of the most common sleep disorders with a high estimated global prevalence and a large number of associated comorbidities in general as well as specific neuropsychiatric complications such as cognitive impairment. The complex pathogenesis and effects of the disorder including chronic intermittent hypoxia and sleep fragmentation may lead to enhanced neuronal damage, thereby contributing to neuropsychiatric pathologies. Obstructive sleep apnea has been described as an independent risk factor for several neurodegenerative diseases, including Alzheimer's disease and all-cause dementia. The influence of obstructive sleep apnea on cognitive deficits is still a topic of recent debate, and several mechanisms, including neurodegeneration and depression-related cognitive dysfunction, underlying this correlation are taken into consideration. The differentiation between both pathomechanisms of cognitive impairment in obstructive sleep apnea is a complex clinical issue, requiring the use of multiple and costly diagnostic methods. The studies conducted on neuroprotection biomarkers, such as brain-derived neurotrophic factors and neurofilaments, are recently gaining ground in the topic of cognition assessment in obstructive sleep apnea patients. Neurofilaments as neuron-specific cytoskeletal proteins could be useful non-invasive indicators of brain conditions and neurodegeneration, which already are observed in many neurological diseases leading to cognitive deficits. Additionally, neurofilaments play an important role as a biomarker in other sleep disorders such as insomnia. Thus, this review summarizes the current knowledge on the involvement of neurofilaments in cognitive decline and neurodegeneration in obstructive sleep apnea patients as well as discusses its possible role as a biomarker of these changes. |
| first_indexed | 2024-03-09T10:46:35Z |
| format | Article |
| id | doaj.art-8174b738c12042998a8b569235146fe4 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-09T10:46:35Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-8174b738c12042998a8b569235146fe42023-12-01T09:57:42ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-11-011410.3389/fpsyt.2023.12893671289367Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarkerJulia Jaromirska0Piotr Kaczmarski1Dominik Strzelecki2Marcin Sochal3Piotr Białasiewicz4Agata Gabryelska5Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandObstructive sleep apnea is one of the most common sleep disorders with a high estimated global prevalence and a large number of associated comorbidities in general as well as specific neuropsychiatric complications such as cognitive impairment. The complex pathogenesis and effects of the disorder including chronic intermittent hypoxia and sleep fragmentation may lead to enhanced neuronal damage, thereby contributing to neuropsychiatric pathologies. Obstructive sleep apnea has been described as an independent risk factor for several neurodegenerative diseases, including Alzheimer's disease and all-cause dementia. The influence of obstructive sleep apnea on cognitive deficits is still a topic of recent debate, and several mechanisms, including neurodegeneration and depression-related cognitive dysfunction, underlying this correlation are taken into consideration. The differentiation between both pathomechanisms of cognitive impairment in obstructive sleep apnea is a complex clinical issue, requiring the use of multiple and costly diagnostic methods. The studies conducted on neuroprotection biomarkers, such as brain-derived neurotrophic factors and neurofilaments, are recently gaining ground in the topic of cognition assessment in obstructive sleep apnea patients. Neurofilaments as neuron-specific cytoskeletal proteins could be useful non-invasive indicators of brain conditions and neurodegeneration, which already are observed in many neurological diseases leading to cognitive deficits. Additionally, neurofilaments play an important role as a biomarker in other sleep disorders such as insomnia. Thus, this review summarizes the current knowledge on the involvement of neurofilaments in cognitive decline and neurodegeneration in obstructive sleep apnea patients as well as discusses its possible role as a biomarker of these changes.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1289367/fullobstructive sleep apneachronic intermittent hypoxianeurofilamentscognitive impairmentbiomarkersneurodegeneration |
| spellingShingle | Julia Jaromirska Piotr Kaczmarski Dominik Strzelecki Marcin Sochal Piotr Białasiewicz Agata Gabryelska Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker Frontiers in Psychiatry obstructive sleep apnea chronic intermittent hypoxia neurofilaments cognitive impairment biomarkers neurodegeneration |
| title | Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker |
| title_full | Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker |
| title_fullStr | Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker |
| title_full_unstemmed | Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker |
| title_short | Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker |
| title_sort | shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker |
| topic | obstructive sleep apnea chronic intermittent hypoxia neurofilaments cognitive impairment biomarkers neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1289367/full |
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