MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug.
Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transf...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0214900 |
| _version_ | 1818725220918231040 |
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| author | Aline Alfaro Andrea León Emanuel Guajardo-Correa Patricia Reúquen Francisco Torres Mario Mery Rodrigo Segura Paula A Zapata Pedro A Orihuela |
| author_facet | Aline Alfaro Andrea León Emanuel Guajardo-Correa Patricia Reúquen Francisco Torres Mario Mery Rodrigo Segura Paula A Zapata Pedro A Orihuela |
| author_sort | Aline Alfaro |
| collection | DOAJ |
| description | Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy. |
| first_indexed | 2024-12-17T21:38:51Z |
| format | Article |
| id | doaj.art-8178080b33d54c57b25d443cada3c5e5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T21:38:51Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8178080b33d54c57b25d443cada3c5e52022-12-21T21:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01148e021490010.1371/journal.pone.0214900MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug.Aline AlfaroAndrea LeónEmanuel Guajardo-CorreaPatricia ReúquenFrancisco TorresMario MeryRodrigo SeguraPaula A ZapataPedro A OrihuelaNovel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy.https://doi.org/10.1371/journal.pone.0214900 |
| spellingShingle | Aline Alfaro Andrea León Emanuel Guajardo-Correa Patricia Reúquen Francisco Torres Mario Mery Rodrigo Segura Paula A Zapata Pedro A Orihuela MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. PLoS ONE |
| title | MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. |
| title_full | MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. |
| title_fullStr | MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. |
| title_full_unstemmed | MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. |
| title_short | MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. |
| title_sort | mgo nanoparticles coated with polyethylene glycol as carrier for 2 methoxyestradiol anticancer drug |
| url | https://doi.org/10.1371/journal.pone.0214900 |
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