Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus

Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus

Several studies demonstrated that mitochondrial dynamics and metabolic pathways control T cell fate in the periphery. However, little is known about their implication in thymocyte development. Our results showed that thymic progenitors (CD3-CD4-CD8- triple negative, TN), in active division, have ess...

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Bibliographic Details
Main Authors: Rima Elhage, Mairead Kelly, Nicolas Goudin, Jérôme Megret, Agnès Legrand, Ivan Nemazanyy, Cécilia Patitucci, Véronique Quellec, Timothy Wai, Ahmed Hamaï, Sophie Ezine
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
thymus
T cell progenitors
β-selection checkpoint
mitochondrial dynamics
metabolome
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270268/full

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