Research advances in the function of ferroptosis in ocular disease
Ferroptosis is a novel form of cell death that has been discovered in recent years and differs markedly from previously known cell death. The mechanism of ferroptosis is the inactivation of glutathione peroxidase(GPX)and the accumulation of lethal intracellular lipid peroxides that occur on the basi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-06-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/6/202306013.pdf |
| _version_ | 1797816807165263872 |
|---|---|
| author | Zi-Xuan Yang Wei Han |
| author_facet | Zi-Xuan Yang Wei Han |
| author_sort | Zi-Xuan Yang |
| collection | DOAJ |
| description | Ferroptosis is a novel form of cell death that has been discovered in recent years and differs markedly from previously known cell death. The mechanism of ferroptosis is the inactivation of glutathione peroxidase(GPX)and the accumulation of lethal intracellular lipid peroxides that occur on the basis of cellular iron overload. Changes such as cell membrane rupture, mitochondrial crest reduction, and outer mitochondrial membrane shrinkage rupture can be observed under electron microscopy. Current studies have found that many diseases in ophthalmology involve ferroptosis-related processes such as iron overload, the imbalance of redox homeostasis, the inactivation of GPX, and accumulation of lethal levels of lipid hydroperoxides, which identified the important role of ferroptosis in ocular disease. This review focuses on the mechanism of ferroptosis and its role in corneal injury, cataract, glaucoma, age-related macular degeneration and diabetic retinopathy, which helps to sort out the pathological mechanisms of common ocular diseases and provide new ideas for the prevention and treatment of ocular diseases. |
| first_indexed | 2024-03-13T08:43:11Z |
| format | Article |
| id | doaj.art-81797c8fe12144ea9d7374fcd24585cc |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-13T08:43:11Z |
| publishDate | 2023-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-81797c8fe12144ea9d7374fcd24585cc2023-05-30T07:55:52ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-06-0123694795210.3980/j.issn.1672-5123.2023.6.13202306013Research advances in the function of ferroptosis in ocular diseaseZi-Xuan Yang0Wei Han1Eye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine;Zhejiang University Eye Hospital, Hangzhou 310009, Zhejiang Province, ChinaEye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine;Zhejiang University Eye Hospital, Hangzhou 310009, Zhejiang Province, ChinaFerroptosis is a novel form of cell death that has been discovered in recent years and differs markedly from previously known cell death. The mechanism of ferroptosis is the inactivation of glutathione peroxidase(GPX)and the accumulation of lethal intracellular lipid peroxides that occur on the basis of cellular iron overload. Changes such as cell membrane rupture, mitochondrial crest reduction, and outer mitochondrial membrane shrinkage rupture can be observed under electron microscopy. Current studies have found that many diseases in ophthalmology involve ferroptosis-related processes such as iron overload, the imbalance of redox homeostasis, the inactivation of GPX, and accumulation of lethal levels of lipid hydroperoxides, which identified the important role of ferroptosis in ocular disease. This review focuses on the mechanism of ferroptosis and its role in corneal injury, cataract, glaucoma, age-related macular degeneration and diabetic retinopathy, which helps to sort out the pathological mechanisms of common ocular diseases and provide new ideas for the prevention and treatment of ocular diseases.http://ies.ijo.cn/cn_publish/2023/6/202306013.pdfferroptosisiron metabolismcorneal diseaseage-related macular degenerationdiabetic retinopathy |
| spellingShingle | Zi-Xuan Yang Wei Han Research advances in the function of ferroptosis in ocular disease Guoji Yanke Zazhi ferroptosis iron metabolism corneal disease age-related macular degeneration diabetic retinopathy |
| title | Research advances in the function of ferroptosis in ocular disease |
| title_full | Research advances in the function of ferroptosis in ocular disease |
| title_fullStr | Research advances in the function of ferroptosis in ocular disease |
| title_full_unstemmed | Research advances in the function of ferroptosis in ocular disease |
| title_short | Research advances in the function of ferroptosis in ocular disease |
| title_sort | research advances in the function of ferroptosis in ocular disease |
| topic | ferroptosis iron metabolism corneal disease age-related macular degeneration diabetic retinopathy |
| url | http://ies.ijo.cn/cn_publish/2023/6/202306013.pdf |
| work_keys_str_mv | AT zixuanyang researchadvancesinthefunctionofferroptosisinoculardisease AT weihan researchadvancesinthefunctionofferroptosisinoculardisease |