Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres
The drive of this exploration is to investigate the mucoadhesive assets of A. indica (Azadirachta indica) fruit mucilage by incorporating it into mucoadhesive microspheres with Acyclovir (AVR) as a model drug. The study was performed to check the impact of the mucilage proportion on particle size a...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2023-04-01
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| Series: | Baghdad Science Journal |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6786 |
| _version_ | 1797854407291830272 |
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| author | Gorantla Naresh Babu Menaka Muthukaruppan Hindustan Abdul Ahad |
| author_facet | Gorantla Naresh Babu Menaka Muthukaruppan Hindustan Abdul Ahad |
| author_sort | Gorantla Naresh Babu |
| collection | DOAJ |
| description |
The drive of this exploration is to investigate the mucoadhesive assets of A. indica (Azadirachta indica) fruit mucilage by incorporating it into mucoadhesive microspheres with Acyclovir (AVR) as a model drug. The study was performed to check the impact of the mucilage proportion on particle size and swelling index. Nine batches of AVR mucoadhesive microspheres were made with varying proportions of Polyacrylic acid 934P and A. indica fruit mucilage (AIFM). A central composite design with design expert software to check the impact of dependent variables (A. indica mucilage and Polyacrylic acid 934 P levels) on particle size and swelling index as a response. As part of congeniality studies, the batches were examined for their physical constraints, AVR contents, and liberation. The particle size was found to be 35.2±0.3-48.1±0.6μm. In batch B-1, the particle was least sized compared to the larger size in B-5. The investigation found that the particle size and the swelling index depended on AIFM and Polyacrylic acid proportions. The research discovered that AVR was systematically released in a controlled manner and that the entrapment efficacy, mucoadhesion, drug content, and other constraints were found to be good. Acyclovir is capable of good stomach-specific drug delivery by Polyacrylic acid 934P and enhanced by A. indica fruit mucilage when prepared as mucoadhesive microspheres. Scanning electron microscopy reveals that the microspheres were spherical with a fairly smooth surface.
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| first_indexed | 2024-04-09T20:06:35Z |
| format | Article |
| id | doaj.art-817ac53a1a5b48b787747df7b8c3789f |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-04-09T20:06:35Z |
| publishDate | 2023-04-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-817ac53a1a5b48b787747df7b8c3789f2023-04-01T19:39:49ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862023-04-0120210.21123/bsj.2022.6786Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres Gorantla Naresh Babu0Menaka Muthukaruppan1Hindustan Abdul Ahad2Research Scholar, Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu-515001, Andhra Pradesh, India. The drive of this exploration is to investigate the mucoadhesive assets of A. indica (Azadirachta indica) fruit mucilage by incorporating it into mucoadhesive microspheres with Acyclovir (AVR) as a model drug. The study was performed to check the impact of the mucilage proportion on particle size and swelling index. Nine batches of AVR mucoadhesive microspheres were made with varying proportions of Polyacrylic acid 934P and A. indica fruit mucilage (AIFM). A central composite design with design expert software to check the impact of dependent variables (A. indica mucilage and Polyacrylic acid 934 P levels) on particle size and swelling index as a response. As part of congeniality studies, the batches were examined for their physical constraints, AVR contents, and liberation. The particle size was found to be 35.2±0.3-48.1±0.6μm. In batch B-1, the particle was least sized compared to the larger size in B-5. The investigation found that the particle size and the swelling index depended on AIFM and Polyacrylic acid proportions. The research discovered that AVR was systematically released in a controlled manner and that the entrapment efficacy, mucoadhesion, drug content, and other constraints were found to be good. Acyclovir is capable of good stomach-specific drug delivery by Polyacrylic acid 934P and enhanced by A. indica fruit mucilage when prepared as mucoadhesive microspheres. Scanning electron microscopy reveals that the microspheres were spherical with a fairly smooth surface. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6786Acyclovir, Azadirachta indica, Microspheres, Mucoadhesive, Particle size |
| spellingShingle | Gorantla Naresh Babu Menaka Muthukaruppan Hindustan Abdul Ahad Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres Baghdad Science Journal Acyclovir, Azadirachta indica, Microspheres, Mucoadhesive, Particle size |
| title | Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres |
| title_full | Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres |
| title_fullStr | Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres |
| title_full_unstemmed | Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres |
| title_short | Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres |
| title_sort | impact of azadirachta indica fruit mucilage on particle size and swelling index in central composite designed acyclovir mucoadhesive microspheres |
| topic | Acyclovir, Azadirachta indica, Microspheres, Mucoadhesive, Particle size |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6786 |
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