CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population
<b>Background:</b> Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is a polygenic disease and is associated with autoimmunity with an unknown etiology.<b> Aims:...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2010;volume=55;issue=1;spage=29;epage=32;aulast=Deeba |
| Summary: | <b>Background:</b> Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is a polygenic disease and is associated with autoimmunity with an unknown etiology.<b> Aims:</b> One of the candidate genes which has a strong association with several autoimmune diseases is ctla0 -4 gene located in chromosome 2q33 region. We investigated the possible association between ctla0 -4 gene polymorphism in exon 1 (A49G) and vitiligo in patients from South India and compared the distribution of this polymorphism to matched control groups. <b> Patients and</b> <b> Methods:</b> The polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 175 patients and 180 normal, age/ethnicity matched individuals. Consistency of genotype frequencies with the Hardy-Weinberg equilibrium was tested using a ÷<sup>2</sup> test. <b> Results:</b> There was no significant difference between the genotype (<i>P</i>=0.93) and allele (<i>P</i>=0 .615) frequencies of CTLA-4 A49G polymorphism in patients and normal healthy individuals. However there was significant association of the CTLA-4 genotype (<i> P</i>=0.02) and allelic frequency (<i> P</i>=0.008) between the segmental and non-segmental sub groups within vitiligo. <b> Conclusion:</b> Our results indicate that there is no association between <i> CTLA</i>-4</i> A49G</i> gene polymorphism and vitiligo in southern Indian population. |
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| ISSN: | 0019-5154 1998-3611 |