Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice

Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice

The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication. During this process, cells must ensure an accurate and complete genome replication when constantly challenged by the presence of DNA lesions. Post-translational modifications of PCNA play a crucial role in chann...

Full description

Bibliographic Details
Main Authors:	Gemma Bellí, Neus Colomina, Laia Castells-Roca, Neus P. Lorite
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Journal of Fungi
Subjects:	PCNA DNA damage tolerance DNA replication stress fungal genome stability DNA replication forks post-translational modifications
Online Access:	https://www.mdpi.com/2309-608X/8/6/621

Similar Items

The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast
by: Sanjeeta Tamang, et al.
Published: (2019-05-01)

EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization
by: Peng A, et al.
Published: (2018-08-01)

Human PCNA Structure, Function and Interactions
by: Amaia González-Magaña, et al.
Published: (2020-04-01)

Multistep loading of a DNA sliding clamp onto DNA by replication factor C
by: Marina Schrecker, et al.
Published: (2022-08-01)

Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair
by: Fengwei Zheng, et al.
Published: (2022-07-01)

Speed variations of bacterial replisomes
by: Deepak Bhat, et al.
Published: (2022-07-01)

Novel mechanism of PCNA control through acetylation of its sliding surface
by: Pierre Billon, et al.
Published: (2017-03-01)

Canonical binding of Chaetomium thermophilum DNA polymerase δ/ζ subunit PolD3 and flap endonuclease Fen1 to PCNA
by: Magnus S. Alphey, et al.
Published: (2023-12-01)

Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers
by: Martin Liptay, et al.
Published: (2020-05-01)

Efficient Arrangement of the Replication Fork Trap for In Vitro Propagation of Monomeric Circular DNA in the Chromosome-Replication Cycle Reaction
by: Tomonori Hasebe, et al.
Published: (2018-09-01)

The Yeast PCNA Unloader Elg1 RFC-Like Complex Plays a Role in Eliciting the DNA Damage Checkpoint
by: Soumitra Sau, et al.
Published: (2019-06-01)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
by: Li Phing Liew, et al.
Published: (2016-11-01)

Forks on the Run: Can the Stalling of DNA Replication Promote Epigenetic Changes?
by: Hollie Rowlands, et al.
Published: (2017-06-01)

Molecular Targeting of Cancer-Associated PCNA Interactions in Pancreatic Ductal Adenocarcinoma Using a Cell-Penetrating Peptide
by: Shanna J. Smith, et al.
Published: (2020-06-01)

Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse
by: Michael O Nguyen, et al.
Published: (2015-03-01)

The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast
by: Io Nam Wong, et al.
Published: (2019-12-01)

<i>DNA2</i> in Chromosome Stability and Cell Survival—Is It All about Replication Forks?
by: Jessica J. R. Hudson, et al.
Published: (2021-04-01)

Regulation of DNA Replication Licensing and Re-Replication by Cdt1
by: Hui Zhang
Published: (2021-05-01)

Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans
by: Heinz Peter Nasheuer, et al.
Published: (2024-03-01)

PCNA Unloading Is Crucial for the Bypass of DNA Lesions Using Homologous Recombination
by: Matan Arbel-Groissman, et al.
Published: (2024-03-01)

DDK: The Outsourced Kinase of Chromosome Maintenance
by: Peter J. Gillespie, et al.
Published: (2022-06-01)

Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans
by: Shraddheya Kumar Patel, et al.
Published: (2023-12-01)

Inhibition of histone methyltransferase SETD8 represses DNA virus replication
by: Lin Chen, et al.
Published: (2022-06-01)

Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication
by: Carl A Morrow, et al.
Published: (2017-06-01)

Replication Stress and Consequential Instability of the Genome and Epigenome
by: Pawlos S. Tsegay, et al.
Published: (2019-10-01)

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation
by: Roxana E Georgescu, et al.
Published: (2015-04-01)

BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication
by: Christelle de Renty, et al.
Published: (2022-07-01)

PCNA Ubiquitylation: Instructive or Permissive to DNA Damage Tolerance Pathways?
by: Jun Che, et al.
Published: (2021-10-01)

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication
by: Sabrina Florencia Mansilla, et al.
Published: (2020-05-01)

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder
by: Wang, L
Published: (2019)

DNA replication : methods and protocols /
by: Vengrova, Sonya, et al.
Published: (2009)

Unorthodox PCNA Binding by Chromatin Assembly Factor 1
by: Amogh Gopinathan Nair, et al.
Published: (2022-09-01)

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork
by: Joanne Saldanha, et al.
Published: (2023-06-01)

Role and Regulation of Pif1 Family Helicases at the Replication Fork
by: Emory G. Malone, et al.
Published: (2022-03-01)

Ctf4 organizes sister replisomes and Pol α into a replication factory
by: Zuanning Yuan, et al.
Published: (2019-10-01)

The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation
by: Jean-Michel Arbona, et al.
Published: (2018-06-01)

A new role for a tumor-suppressing protein
by: Jeremy S Setton, et al.
Published: (2018-03-01)

DNAscent v2: detecting replication forks in nanopore sequencing data with deep learning
by: Michael A. Boemo
Published: (2021-06-01)

Editorial: DNA Replication Stress and Cell Fate
by: Lin Deng, et al.
Published: (2021-10-01)

GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome
by: Matthew D Sekedat, et al.
Published: (2010-01-01)