Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms
BackgroundAssessing rupture risk in patients with unruptured intracranial aneurysms (UIAs) remains challenging. Hemodynamics plays an important role in the natural history of intracranial aneurysms. This study aimed to compare aneurysmal hemodynamic features between patients with different rupture r...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.818335/full |
| _version_ | 1818060662904979456 |
|---|---|
| author | Zhongbin Tian Xifeng Li Chao Wang Xin Feng Kaijian Sun Yi Tu Hengxian Su Xinjian Yang Chuanzhi Duan |
| author_facet | Zhongbin Tian Xifeng Li Chao Wang Xin Feng Kaijian Sun Yi Tu Hengxian Su Xinjian Yang Chuanzhi Duan |
| author_sort | Zhongbin Tian |
| collection | DOAJ |
| description | BackgroundAssessing rupture risk in patients with unruptured intracranial aneurysms (UIAs) remains challenging. Hemodynamics plays an important role in the natural history of intracranial aneurysms. This study aimed to compare aneurysmal hemodynamic features between patients with different rupture risk as determined by PHASES score.MethodsWe retrospectively examined 238 patients who harbored a solitary saccular UIA. Patients were stratified by rupture risk into low-, intermediate-, and high-risk groups according to PHASES score. Flow simulations were performed to compare differences in hemodynamics among the groups.ResultsAneurysmal time-averaged wall shear stress (WSSa) and normalized WSS (WSSn) decreased progressively as PHASES score increased. WSSa and WSSn significantly differed among the low-, intermediate-, and high-risk groups (p < 0.001). WSSa was significantly lower in the high-risk group than the low-risk group (p < 0.001) and the intermediate-risk group (p = 0.004). WSSn was also significantly lower in the high-risk group than the low-risk group (p < 0.001) and the intermediate-risk group (p = 0.001).ConclusionsLow WSS was significantly associated with higher risk of intracranial aneurysm rupture as determined by PHASES score, indicating that hemodynamics may play an important role in aneurysmal rupture. In the future, a multidimensional rupture risk prediction model that includes hemodynamic parameters should be investigated. |
| first_indexed | 2024-12-10T13:35:59Z |
| format | Article |
| id | doaj.art-817bc5602293445ead579b78b73d2373 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T13:35:59Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-817bc5602293445ead579b78b73d23732022-12-22T01:46:49ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-04-011310.3389/fneur.2022.818335818335Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial AneurysmsZhongbin Tian0Xifeng Li1Chao Wang2Xin Feng3Kaijian Sun4Yi Tu5Hengxian Su6Xinjian Yang7Chuanzhi Duan8National Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaNational Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Neurosurgery, Binzhou Medical University Hospital, Binzhou, ChinaNational Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaNational Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaNational Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaNational Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaNational Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Neurosurgery Institute, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaBackgroundAssessing rupture risk in patients with unruptured intracranial aneurysms (UIAs) remains challenging. Hemodynamics plays an important role in the natural history of intracranial aneurysms. This study aimed to compare aneurysmal hemodynamic features between patients with different rupture risk as determined by PHASES score.MethodsWe retrospectively examined 238 patients who harbored a solitary saccular UIA. Patients were stratified by rupture risk into low-, intermediate-, and high-risk groups according to PHASES score. Flow simulations were performed to compare differences in hemodynamics among the groups.ResultsAneurysmal time-averaged wall shear stress (WSSa) and normalized WSS (WSSn) decreased progressively as PHASES score increased. WSSa and WSSn significantly differed among the low-, intermediate-, and high-risk groups (p < 0.001). WSSa was significantly lower in the high-risk group than the low-risk group (p < 0.001) and the intermediate-risk group (p = 0.004). WSSn was also significantly lower in the high-risk group than the low-risk group (p < 0.001) and the intermediate-risk group (p = 0.001).ConclusionsLow WSS was significantly associated with higher risk of intracranial aneurysm rupture as determined by PHASES score, indicating that hemodynamics may play an important role in aneurysmal rupture. In the future, a multidimensional rupture risk prediction model that includes hemodynamic parameters should be investigated.https://www.frontiersin.org/articles/10.3389/fneur.2022.818335/fullhemodynamicsrupture riskPHASES scoreunruptured intracranial aneurysmwall shear stress |
| spellingShingle | Zhongbin Tian Xifeng Li Chao Wang Xin Feng Kaijian Sun Yi Tu Hengxian Su Xinjian Yang Chuanzhi Duan Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms Frontiers in Neurology hemodynamics rupture risk PHASES score unruptured intracranial aneurysm wall shear stress |
| title | Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms |
| title_full | Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms |
| title_fullStr | Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms |
| title_full_unstemmed | Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms |
| title_short | Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms |
| title_sort | association between aneurysmal hemodynamics and rupture risk of unruptured intracranial aneurysms |
| topic | hemodynamics rupture risk PHASES score unruptured intracranial aneurysm wall shear stress |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.818335/full |
| work_keys_str_mv | AT zhongbintian associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT xifengli associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT chaowang associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT xinfeng associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT kaijiansun associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT yitu associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT hengxiansu associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT xinjianyang associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms AT chuanzhiduan associationbetweenaneurysmalhemodynamicsandruptureriskofunrupturedintracranialaneurysms |