Dynamical Synergy of Drug Combinations during Cancer Chemotherapy
Synergistic drug combinations often provide effective strategies to increase treatment efficacy and, during therapy, it is a time-dependent process. Data for colorectal and lung cancer in vivo were used for the phenomenological study of dynamical synergy during treatments. The proposed approach take...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/11/1873 |
| _version_ | 1797467655671644160 |
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| author | Paolo Castorina Emanuele Martorana Stefano Forte |
| author_facet | Paolo Castorina Emanuele Martorana Stefano Forte |
| author_sort | Paolo Castorina |
| collection | DOAJ |
| description | Synergistic drug combinations often provide effective strategies to increase treatment efficacy and, during therapy, it is a time-dependent process. Data for colorectal and lung cancer in vivo were used for the phenomenological study of dynamical synergy during treatments. The proposed approach takes into consideration tumor regrowth by macroscopic laws. The time dependencies of synergistic drug combinations are analyzed by different parametric indicators. The cumulative effects of the single therapy and drug combinations are quantitatively well described and related to the cumulative doses. In conclusion, the analysis of dynamical synergy during chemotherapy has to take into account the effects of the drug doses and the tumor regrowth, which can provide a reliable description of the synergistic time dependence. |
| first_indexed | 2024-03-09T18:55:50Z |
| format | Article |
| id | doaj.art-817e0074edc7471fad6350b01561e7bd |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T18:55:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-817e0074edc7471fad6350b01561e7bd2023-11-24T05:26:34ZengMDPI AGJournal of Personalized Medicine2075-44262022-11-011211187310.3390/jpm12111873Dynamical Synergy of Drug Combinations during Cancer ChemotherapyPaolo Castorina0Emanuele Martorana1Stefano Forte2INFN, Sezione di Catania, I-95123 Catania, ItalyIstituto Oncologico del Mediterraneo, 95029 Viagrande, ItalyIstituto Oncologico del Mediterraneo, 95029 Viagrande, ItalySynergistic drug combinations often provide effective strategies to increase treatment efficacy and, during therapy, it is a time-dependent process. Data for colorectal and lung cancer in vivo were used for the phenomenological study of dynamical synergy during treatments. The proposed approach takes into consideration tumor regrowth by macroscopic laws. The time dependencies of synergistic drug combinations are analyzed by different parametric indicators. The cumulative effects of the single therapy and drug combinations are quantitatively well described and related to the cumulative doses. In conclusion, the analysis of dynamical synergy during chemotherapy has to take into account the effects of the drug doses and the tumor regrowth, which can provide a reliable description of the synergistic time dependence.https://www.mdpi.com/2075-4426/12/11/1873synergydrug combinationchemotherapytumor progression |
| spellingShingle | Paolo Castorina Emanuele Martorana Stefano Forte Dynamical Synergy of Drug Combinations during Cancer Chemotherapy Journal of Personalized Medicine synergy drug combination chemotherapy tumor progression |
| title | Dynamical Synergy of Drug Combinations during Cancer Chemotherapy |
| title_full | Dynamical Synergy of Drug Combinations during Cancer Chemotherapy |
| title_fullStr | Dynamical Synergy of Drug Combinations during Cancer Chemotherapy |
| title_full_unstemmed | Dynamical Synergy of Drug Combinations during Cancer Chemotherapy |
| title_short | Dynamical Synergy of Drug Combinations during Cancer Chemotherapy |
| title_sort | dynamical synergy of drug combinations during cancer chemotherapy |
| topic | synergy drug combination chemotherapy tumor progression |
| url | https://www.mdpi.com/2075-4426/12/11/1873 |
| work_keys_str_mv | AT paolocastorina dynamicalsynergyofdrugcombinationsduringcancerchemotherapy AT emanuelemartorana dynamicalsynergyofdrugcombinationsduringcancerchemotherapy AT stefanoforte dynamicalsynergyofdrugcombinationsduringcancerchemotherapy |