Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into domain organization, multimerization, RNA binding, a...

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Bibliographic Details
Main Authors: Hanjing Yang, Fumiaki Ito, Aaron D. Wolfe, Shuxing Li, Nazanin Mohammadzadeh, Robin P. Love, Maocai Yan, Brett Zirkle, Amit Gaba, Linda Chelico, Xiaojiang S. Chen
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14377-y

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