Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy?
There is substantial evidence to suggest that complete tumor eradication relies on the effective elimination of cancer stem cells (CSCs). CSCs have been widely described as mediators of resistance to conventional therapies, including chemo- and radiotherapy, as well as of tumor metastasization and r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.877384/full |
| _version_ | 1818058361420120064 |
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| author | Roberto Ruiu Antonino Di Lorenzo Federica Cavallo Laura Conti |
| author_facet | Roberto Ruiu Antonino Di Lorenzo Federica Cavallo Laura Conti |
| author_sort | Roberto Ruiu |
| collection | DOAJ |
| description | There is substantial evidence to suggest that complete tumor eradication relies on the effective elimination of cancer stem cells (CSCs). CSCs have been widely described as mediators of resistance to conventional therapies, including chemo- and radiotherapy, as well as of tumor metastasization and relapse in different tumor types, including breast cancer. However, the resistant phenotype of CSCs makes their targeting a tough task, and immunotherapy may therefore be an interesting option. Nevertheless, although immunotherapeutic approaches to cancer treatment have generated great enthusiasm due to recent success in clinics, breast cancer treatment mostly relies on standard approaches. In this context, we review the existing literature on the immunological properties of breast CSC and immunotherapeutic approaches to them. We will thus attempt to clarify whether there is room for the immunotargeting of breast CSCs in the current landscape of breast cancer therapies. Finally, we will provide our opinion on the CSC-targeting immunotherapeutic strategies that could prospectively be attempted. |
| first_indexed | 2024-12-10T12:59:24Z |
| format | Article |
| id | doaj.art-8184b94309734dd98317860b01812f27 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T12:59:24Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8184b94309734dd98317860b01812f272022-12-22T01:47:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.877384877384Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy?Roberto RuiuAntonino Di LorenzoFederica CavalloLaura ContiThere is substantial evidence to suggest that complete tumor eradication relies on the effective elimination of cancer stem cells (CSCs). CSCs have been widely described as mediators of resistance to conventional therapies, including chemo- and radiotherapy, as well as of tumor metastasization and relapse in different tumor types, including breast cancer. However, the resistant phenotype of CSCs makes their targeting a tough task, and immunotherapy may therefore be an interesting option. Nevertheless, although immunotherapeutic approaches to cancer treatment have generated great enthusiasm due to recent success in clinics, breast cancer treatment mostly relies on standard approaches. In this context, we review the existing literature on the immunological properties of breast CSC and immunotherapeutic approaches to them. We will thus attempt to clarify whether there is room for the immunotargeting of breast CSCs in the current landscape of breast cancer therapies. Finally, we will provide our opinion on the CSC-targeting immunotherapeutic strategies that could prospectively be attempted.https://www.frontiersin.org/articles/10.3389/fonc.2022.877384/fullbreast cancercancer stem cellsimmunotherapyCAR-Tvaccinationmonoclonal antibody |
| spellingShingle | Roberto Ruiu Antonino Di Lorenzo Federica Cavallo Laura Conti Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy? Frontiers in Oncology breast cancer cancer stem cells immunotherapy CAR-T vaccination monoclonal antibody |
| title | Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy? |
| title_full | Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy? |
| title_fullStr | Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy? |
| title_full_unstemmed | Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy? |
| title_short | Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy? |
| title_sort | are cancer stem cells a suitable target for breast cancer immunotherapy |
| topic | breast cancer cancer stem cells immunotherapy CAR-T vaccination monoclonal antibody |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.877384/full |
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